Biomarkers are detectable molecules that can reflect specific physiological states of cells,
organs, and organisms and therefore be regarded as indicators for specific diseases. And …

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality
worldwide. COPD heterogeneity has hampered progress in developing pharmacotherapies …

Understanding how genetic variants influence disease risk and complex traits (variant-to-
function) is one of the major challenges in human genetics. Here we present a model-driven …

Objective To overcome the limitations associated with the collection and curation of COVID-
19 outcome data in biobanks, this study proposes the use of polygenic risk scores (PRS) as …

Multi-omic analysis is an effective approach for dissecting the mechanisms of diseases;
however, collecting multi-omic data in large populations is time-consuming and costly …

Background Pulmonary arterial hypertension (PAH) exhibits phenotypic heterogeneity and
variable response to therapy. The metabolome has been implicated in the pathogenesis of …

Background Quantitative nuclear magnetic resonance (NMR) metabolomics techniques
provide detailed measurements of lipoprotein particle concentration. Metabolic dysfunction …

1H-NMR metabolomics data is increasingly used to track health and disease. Nightingale
Health, a major supplier of 1H-NMR metabolomics, has recently updated the quantification …

Our genomes influence nearly every aspect of human biology from molecular and cellular
functions to phenotypes in health and disease. Human genetics studies have now …

Genes on the X-chromosome are extensively expressed in the human brain, resulting in
substantial influences on brain development, intellectual disability, and other brain-related …