Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms

A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Traumatic spinal cord injury

CS Ahuja, JR Wilson, S Nori, M Kotter… - Nature reviews Disease …, 2017 - nature.com
Traumatic spinal cord injury (SCI) has devastating consequences for the physical, social and
vocational well-being of patients. The demographic of SCIs is shifting such that an …

Transplanting neural progenitor cells to restore connectivity after spinal cord injury

I Fischer, JN Dulin, MA Lane - Nature Reviews Neuroscience, 2020 - nature.com
Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

Restorative effects of human neural stem cell grafts on the primate spinal cord

ES Rosenzweig, JH Brock, P Lu, H Kumamaru… - Nature medicine, 2018 - nature.com
We grafted human spinal cord–derived neural progenitor cells (NPCs) into sites of cervical
spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug …

Rat models of spinal cord injury: from pathology to potential therapies

J Kjell, L Olson - Disease models & mechanisms, 2016 - journals.biologists.com
ABSTRACT A long-standing goal of spinal cord injury research is to develop effective spinal
cord repair strategies for the clinic. Rat models of spinal cord injury provide an important …

Single-cell analysis reveals region-heterogeneous responses in rhesus monkey spinal cord with complete injury

Y Fan, X Wu, S Han, Q Zhang, Z Sun, B Chen… - Nature …, 2023 - nature.com
Spinal cord injury (SCI) leads to severe sensory and motor dysfunction below the lesion.
However, the cellular dynamic responses and heterogeneity across different regions below …

Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury

S Kabu, Y Gao, BK Kwon, V Labhasetwar - Journal of Controlled Release, 2015 - Elsevier
Spinal cord injury (SCI) results in devastating neurological and pathological consequences,
causing major dysfunction to the motor, sensory, and autonomic systems. The primary …

Comparative neuroanatomy of the lumbosacral spinal cord of the rat, cat, pig, monkey, and human

A Toossi, B Bergin, M Marefatallah, B Parhizi… - Scientific Reports, 2021 - nature.com
The overall goal of this work was to create a high-resolution MRI atlas of the lumbosacral
enlargement of the spinal cord of the rat (Sprague–Dawley), cat, domestic pig, rhesus …

Mesenchymal stromal cell therapy in bronchopulmonary dysplasia: systematic review and meta-analysis of preclinical studies

S Augustine, MT Avey, B Harrison… - Stem cells …, 2017 - academic.oup.com
Extreme prematurity is the leading cause of death among children under 5 years of age.
Currently, there is no treatment for bronchopulmonary dysplasia (BPD), the most common …

Emerging safety of intramedullary transplantation of human neural stem cells in chronic cervical and thoracic spinal cord injury

AD Levi, DO Okonkwo, P Park, AL Jenkins III… - …, 2018 - journals.lww.com
BACKGROUND Human central nervous system stem cells (HuCNS-SC) are multipotent
adult stem cells with successful engraftment, migration, and region-appropriate …