2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of immunity in THP-1-derived macrophages and the possible mechanisms

X Li, N Li, Y Han, K Rao, X Ji, M Ma - Environmental Pollution, 2021 - Elsevier
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is a well-known immunotoxic
environmental pollutant. However, most immunotoxicology studies of TCDD were based on …

PCB126 exposure revealed alterations in m6A RNA modifications in transcripts associated with AHR activation

N Aluru, SI Karchner - Toxicological Sciences, 2021 - academic.oup.com
Chemical modifications of proteins, DNA, and RNA moieties play critical roles in regulating
gene expression. Emerging evidence suggests the RNA modifications (epitranscriptomics) …

Environmentally relevant concentrations of 2, 3, 7, 8-TCDD induced inhibition of multicellular alternative splicing and transcriptional dysregulation

B Zhao, J Deng, M Ma, N Li, J Zhou, X Li… - Science of The Total …, 2024 - Elsevier
Alternative splicing (AS), found in approximately 95% of human genes, significantly
amplifies protein diversity and is implicated in disease pathogenesis when dysregulated …

Integrating gene expression and splicing dynamics across dose-response oxidative modulators

AR Barutcu, MB Black, R Samuel, S Slattery… - Frontiers in …, 2024 - frontiersin.org
Toxicological risk assessment increasingly utilizes transcriptomics to derive point of
departure (POD) and modes of action (MOA) for chemicals. One essential biological process …

Global transcriptome modulation by xenobiotics: the role of alternative splicing in adaptive responses to chemical exposures

AJ Annalora, JL Coburn, A Jozic, PL Iversen… - Human Genomics, 2024 - Springer
Background Xenobiotic exposures can extensively influence the expression and alternative
splicing of drug-metabolizing enzymes, including cytochromes P450 (CYPs), though their …

Review of gene expression using microarray and RNA-seq

AB Villaseñor-Altamirano, YI Balderas-Martínez… - … and Reproducibility in …, 2024 - Elsevier
In this chapter, we review the history of high-throughput technologies to measure gene
expression, and we describe basic approaches to analyze transcriptome data, together with …

De novo assembly and annotation of a highly contiguous reference genome of the fathead minnow (Pimephales promelas) reveals an AT-rich repetitive genome with …

J Martinson, DC Bencic, GP Toth, MS Kostich, RW Flick… - BioRxiv, 2021 - biorxiv.org
ABSTRACT The Fathead Minnow (FHM) is one of the most important and widely used model
organisms in aquatic toxicology. The lack of a high-quality and well-annotated FHM …

Epitranscriptomic regulation in breast cancer and PCB-induced liver disease.

B Petri - 2023 - ir.library.louisville.edu
Post-transcriptional RNA modifications including N6-methyladenosine (m6A) regulate
mRNA stability, splicing, and translation. My research examined m6A in two disease models …

Viral Infections or Chemical Exposure and Their Association With Parkinson's Disease or Lewy Body Dementia in the United States (2000–2010) in Older Adults

ND Marchan - 2024 - search.proquest.com
Background: Parkinson's disease (PD) and Lewy body dementia (LBD) are degenerative
neurological diseases primarily affecting older adults. LBD encompasses dementia with …

[引用][C] Alternative splicing in the nuclear receptor superfamily expands gene function to refine endo-xenobiotic metabolism

AJ Annalora, CB Marcus, PL Iversen - Drug Metabolism and Disposition, 2020 - ASPET