▪ Abstract The ATP-binding cassette (ABC) transporters are a family of large proteins in
membranes and are able to transport a variety of compounds through membranes against …

Multidrug resistance proteins (MRPs) are members of the C family of a group of proteins
named ATP-binding cassette (ABC) transporters. These ABC transporters together form the …

Cellular export of cyclic nucleotides has been observed in various tissues and may
represent an elimination pathway for these signaling molecules, in addition to degradation …

Human multidrug resistance protein 4 (MRP4) has recently been determined to confer
resistance to the antiviral purine analog 9-(2-phosphonylmethoxyethyl) adenine and …

We summarize in this paper the recently published results on multidrug resistance-
associated proteins 3, 4, and 5 (MRPs 3–5). MRP3 can transport organic compounds …

MRP8 (ABCC11) is a recently identified cDNA that has been assigned to the multidrug
resistance-associated protein (MRP) family of ATP-binding cassette transporters, but its …

Like other members of the multidrug resistance protein (MRP)/ABCC subfamily of ATP-
binding cassette transporters, MRP4 (ABCC4) and MRP5 (ABCC5) are organic anion …

Nucleotide efflux (especially cyclic nucleotides) from a variety of mammalian tissues,
bacteria, and lower eukaryotes has been studied for several decades. However, the …

The biokinetics of guanosine 3′, 5′-cyclic monophosphate (cGMP) is characterized by
three distinct processes: synthesis by guanylate cyclases (GCs), conversion of cGMP to …

cGMP secretion from cells can be mediated by ATP‐binding cassette (ABC) transporters
ABCC4, ABCC5, and ABCC11. Indirect evidence suggests that ABCC4 and ABCC5 …