[HTML][HTML] Gene-environment interactions in schizophrenia: a literature review

MH Wahbeh, D Avramopoulos - Genes, 2021 - mdpi.com
Schizophrenia is a devastating mental illness with a strong genetic component that is the
subject of extensive research. Despite the high heritability, it is well recognized that non …

Modeling psychotic disorders: environment x environment interaction

K Murlanova, MV Pletnikov - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Schizophrenia is a major psychotic disorder with multifactorial etiology that includes
interactions between genetic vulnerability and environmental risk factors. In addition …

Gene–environment interaction using polygenic scores: Do polygenic scores for psychopathology moderate predictions from environmental risk to behavior problems?

R Plomin, A Gidziela, M Malanchini… - Development and …, 2022 - cambridge.org
The DNA revolution has energized research on interactions between genes and
environments (GxE) by creating indices of G (polygenic scores) that are powerful predictors …

[HTML][HTML] The epidemiology and global burden of schizophrenia

DI Velligan, S Rao - The Journal of clinical psychiatry, 2023 - psychiatrist.com
Schizophrenia is a psychiatric syndrome characterized by delusions, disorganized speech,
hallucinations, and impaired executive functioning. Affecting approximately 1% of the global …

[HTML][HTML] Using animal models for the studies of schizophrenia and depression: The value of translational models for treatment and prevention

DL Uliana, X Zhu, FV Gomes, AA Grace - Frontiers in Behavioral …, 2022 - frontiersin.org
Animal models of psychiatric disorders have been highly effective in advancing the field,
identifying circuits related to pathophysiology, and identifying novel therapeutic targets. In …

Brain vasculature disturbance in schizophrenia

S Puvogel, V Palma… - Current opinion in …, 2022 - ingentaconnect.com
Purpose of review The vascular hypothesis of schizophrenia (SZ) postulates that brain
endothelial dysfunction contributes to brain pathophysiology. This review discusses recent …

Toxoplasmosis and Schizophrenia: A Systematic Review and Meta‐Analysis of Prevalence and Associations and Future Directions

DG Contopoulos‐Ioannidis, M Gianniki… - Psychiatric …, 2022 - Am Psychiatric Assoc
Background A potential link between toxoplasmosis with schizophrenia (SCZ) has been
extensively studied over the past 2 decades. Our study was aimed to determine whether …

Environmental Influences on the Relation between the 22q11. 2 Deletion Syndrome and Mental Health: A Literature Review

Y Snihirova, DEJ Linden, T van Amelsvoort… - Genes, 2022 - mdpi.com
22q11. 2 deletion syndrome (22q11DS) is a clinically heterogeneous genetic syndrome,
associated with a wide array of neuropsychiatric symptoms. The clinical presentation is likely …

Allostatic load and systemic comorbidities in psychiatric disorders

S Finlay, D Rudd, B McDermott, Z Sarnyai - Psychoneuroendocrinology, 2022 - Elsevier
Psychiatric disorders are complex, disabling, and chronic conditions that are often
accompanied by one or more systemic medical comorbidities. In this narrative review, we …

Maternal Inflammation with Elevated Kynurenine Metabolites Is Related to the Risk of Abnormal Brain Development and Behavioral Changes in Autism Spectrum …

Y Murakami, Y Imamura, Y Kasahara, C Yoshida… - Cells, 2023 - mdpi.com
Several studies show that genetic and environmental factors contribute to the onset and
progression of neurodevelopmental disorders. Maternal immune activation (MIA) during …