The epidemic nature of diabetes mellitus in different regions is reviewed. The Middle East
and North Africa region has the highest prevalence of diabetes in adults (10.9%) whereas …

Integrating single nucleotide polymorphism (SNP) p-values from genome-wide association
studies (GWAS) across genes and pathways is a strategy to improve statistical power and …

As a member of the Activator Protein-1 (AP-1) transcription factor family, the Basic Leucine
Zipper Transcription Factor (BATF) mediates multiple biological functions of immune cells …

Meta-analysis of multiple genome-wide association studies (GWAS) has become an
effective approach for detecting single nucleotide polymorphism (SNP) associations with …

Motivation Methods for analysis of GWAS summary statistics have encouraged data sharing
and democratized the analysis of different diseases. Ideal validation for such methods is …

A transcriptome‐wide association study (TWAS) attempts to identify disease associated
genes by imputing gene expression into a genome‐wide association study (GWAS) using …

Abstract Diabetic Kidney Disease (DKD), a major precursor to end‐stage renal disease,
involves mitochondrial dysfunction in proximal renal tubular cells (PTCs), contributing to its …

Abstract Type 1 diabetes (T1D) is a complex autoimmune disease in which pancreatic beta
cells are specifically destroyed by the immune system. The disease has an important genetic …

We present shaPRS, a method that leverages widespread pleiotropy between traits or
shared genetic effects across ancestries, to improve the accuracy of polygenic scores. The …

Background: Much of the heritable risk of renal cell carcinoma (RCC) associated with
common genetic variation is unexplained. New analytic approaches have been developed …