Cancer cells can organize and communicate in functional networks. Similarly to other
networks in biology and sociology, these can be highly relevant for growth and resilience. In …

Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …

Astrocytic brain tumours, including glioblastomas, are incurable neoplasms characterized by
diffusely infiltrative growth. Here we show that many tumour cells in astrocytomas extend …

Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …

Background Primary and adaptive resistance against chemo-and radiotherapy and local
recurrence after surgery limit the benefits from these standard treatments in glioma patients …

Shifting the balance away from tumor-mediated immune suppression toward tumor immune
rejection is the conceptual foundation for a variety of immunotherapy efforts currently being …

Glioblastoma ranks among the most lethal of all human cancers. Glioblastomas display
striking cellular heterogeneity, with stem-like glioblastoma stem cells (GSCs) at the apex …

Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer due to its highly
invasive nature that impedes the surgical removal of all tumor cells, making relapse …

Human glioblastoma (GBM) is a highly aggressive, invasive and hypervascularised
malignant brain cancer. Individual circulating tumour cells (CTCs) are sporadically found in …

In many cases, the mechanical properties of a tumor are different from those of the host
tissue. Mechanical cues regulate cancer development by affecting both tumor cells and their …