The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …

Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Cancer is a complex disease characterized by loss of cellular homeostasis through genetic
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …

Histone variants are chromatin components that replace replication-coupled histones in a
fraction of nucleosomes and confer particular characteristics to chromatin. H2A variants …

Conspectus Inhibitor discovery for protein–protein interactions has proven difficult due to the
large protein surface areas and dynamic interfaces involved. This is particularly the case …

NMR is an essential technique for obtaining information at atomic resolution on the structure,
motions and interactions of biomolecules. Here, we review the contribution of NMR to our …

Nucleosome remodeling provides access to genomic DNA for recruitment of the
transcriptional machinery to mediate gene expression. The aberrant function of nucleosome …

Chromatin, the functional organization of DNA with histone proteins in eukaryotic nuclei, is
the tightly-regulated template for several biological processes, such as transcription …

Lysine acylation is a ubiquitous protein modification that controls various aspects of protein
function, such as the activity, localization, and stability of enzymes. Mass spectrometric …

Bromodomain-containing proteins regulate transcription through protein–protein interactions
with chromatin and serve as scaffolding proteins for recruiting essential members of the …