Pancreatic cancer (PC) is a leading cause of cancer related mortality on a global scale. The
disease itself is associated with a dismal prognosis, partly due to its silent nature resulting in …

Carcinoembryonic antigen (CEA)-related cell adhesion molecule 6 (CEACAM6) is a cell
adhesion protein of the CEA family of glycosyl phosphatidyl inositol anchored cell surface …

Abstract N-acetylglucosaminyltransferase-V (GnT-V) alters the structure of specific N-
glycans by modifying α1-6-linked mannose with a β1-6-linked N-acetylglucosamine branch …

Glycosylation is the most ubiquitous post-translational modification in eukaryotes. N-glycan
is attached to nascent glycoproteins and is processed and matured by various glycosidases …

It is well known that numerous cancer-related changes occur in glycans that are attached to
glycoproteins, glycolipids and proteoglycans on the cell surface and these changes in …

Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of all cancers. To
improve PDAC therapy, we establish screening systems based on organoid and co-culture …

Background Changes in protein glycosylation are widely observed in tumor cells. N-glycan
branching through adding β1, 6-linked N-acetylglucosamine (β1, 6-GlcNAc) to an α1, 6 …

Glycosylation is an important posttranslational modification of proteins, and it has a profound
influence on diverse life processes. An abnormal polysaccharide structure and mutation of …

Resistance to androgen deprivation therapy (ADT) is the main challenge for advanced fatal
prostate cancer (PCa), which can gradually develop into metastatic castration-resistant …

Among carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family
proteins, CEACAM6 has received less attention than CEACAM5 and its presence and role in …