Photochemical internalization provides time-and space-controlled endolysosomal escape of therapeutic molecules
PK Selbo, A Weyergang, A Høgset, OJ Norum… - Journal of Controlled …, 2010 - Elsevier
A successful cure of cancer by biopharmaceuticals with intracellular targets is dependent on
both specific and sufficient delivery of the drug to the cytosol or nuclei of malignant cells …
both specific and sufficient delivery of the drug to the cytosol or nuclei of malignant cells …
Photochemical internalization for intracellular drug delivery. From basic mechanisms to clinical research
Photochemical internalisation (PCI) is a unique intervention which involves the release of
endocytosed macromolecules into the cytoplasmic matrix. PCI is based on the use of …
endocytosed macromolecules into the cytoplasmic matrix. PCI is based on the use of …
Endosomal escape pathways for non-viral nucleic acid delivery systems
Nucleic acids, including plasmid DNA (pDNA) and small interfering RNA (siRNA), are
potential therapeutic macromolecules that have been widely explored for the treatment or …
potential therapeutic macromolecules that have been widely explored for the treatment or …
Ribosome-inactivating proteins: from plant defense to tumor attack
M de Virgilio, A Lombardi, R Caliandro, MS Fabbrini - Toxins, 2010 - mdpi.com
Ribosome-inactivating proteins (RIPs) are EC3. 2.32. 22 N-glycosidases that recognize a
universally conserved stem-loop structure in 23S/25S/28S rRNA, depurinating a single …
universally conserved stem-loop structure in 23S/25S/28S rRNA, depurinating a single …
Killing cancer cells by targeted drug-carrying phage nanomedicines
Background Systemic administration of chemotherapeutic agents, in addition to its anti-
tumor benefits, results in indiscriminate drug distribution and severe toxicity. This …
tumor benefits, results in indiscriminate drug distribution and severe toxicity. This …
Saporin-S6: a useful tool in cancer therapy
Thirty years ago, the type 1 ribosome-inactivating protein (RIP) saporin-S6 (also known as
saporin) was isolated from Saponaria officinalis L. seeds. Since then, the properties and …
saporin) was isolated from Saponaria officinalis L. seeds. Since then, the properties and …
Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in …
AA Sultan, W Jerjes, K Berg, A Høgset… - The Lancet …, 2016 - thelancet.com
Background Photochemical internalisation, a novel minimally invasive treatment, has shown
promising preclinical results in enhancing and site-directing the effect of anticancer drugs by …
promising preclinical results in enhancing and site-directing the effect of anticancer drugs by …
Development of gelatin nanoparticles with biotinylated EGF conjugation for lung cancer targeting
Since lung cancer is the most malignant cancer today, a specific drug-delivery system has
been developed for superior outcome. In this study, gelatin nanoparticles (GPs) employed …
been developed for superior outcome. In this study, gelatin nanoparticles (GPs) employed …
Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization
K Berg, S Nordstrand, PK Selbo, DTT Tran… - Photochemical & …, 2011 - Springer
Photochemical internalisation (PCI) is a novel technology for release of endocytosed
macromolecules into the cytosol. The technology is based on the use of photosensitizers …
macromolecules into the cytosol. The technology is based on the use of photosensitizers …
[HTML][HTML] Photochemical internalization (PCI) in cancer therapy: from bench towards bedside medicine
OJ Norum, PK Selbo, A Weyergang… - … of Photochemistry and …, 2009 - Elsevier
PDT in cancer therapy has been reviewed several times recently and many published
reports have been showing promising results. The clinical approvals for PDT include …
reports have been showing promising results. The clinical approvals for PDT include …