S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …

Research on the free radical gas, nitric oxide (NO), during the past twenty years is one of the
most rapid growing areas in biology. NO seems to play a part in almost every organ and …

The mechanisms that permit adult tissues to regenerate when injured are not well
understood. Initiation of liver regeneration requires the injury-related cytokines, tumor …

Two genes (MAT1A and MAT2A) encode for the essential enzyme methionine
adenosyltransferase (MAT), which catalyzes the biosynthesis of S-adenosylmethionine …

The growth‐stimulatory actions of tumor necrosis factor α (TNF‐α) after partial hepatectomy
(PH) are difficult to reconcile with its well‐established role in the genesis of liver injury. The …

The expressions and activities of several CCAAT/enhancer-binding proteins (C/EBP)
isoforms fluctuate in the regenerating liver. The physiological implications of these variations …

The formation of liver metastases involves interactions between intravascular cancer cells
and the hepatic microvasculature. Here we provide evidence that the arrest of intravascular …

The liver has a remarkable ability to regenerate in response to surgical removal or chemical
insult. The mechanisms regulating regenerative processes are complex, and incompletely …

The restitution of epithelial integrity is accomplished in part by cell migration. Studying this
process, we have found that nitric oxide (NO) release migrating epithelial BSC-1 cells …

BACKGROUND & AIMS: Liver regeneration is a fundamental response of this organ to
injury. Hepatocyte proliferation is triggered by growth factors, such as hepatocyte growth …