Cumulus expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan

E Babayev, C Suebthawinkul, D Gokyer… - Aging …, 2023 - Wiley Online Library
Reproductive aging is associated with ovulatory defects. Age‐related ovarian fibrosis
partially contributes to this phenotype as short‐term treatment with anti‐fibrotic compounds …

Glutathione mitigates meiotic defects in porcine oocytes exposed to beta-cypermethrin by regulating ROS levels

Q He, X Zhang, X Yang - Toxicology, 2023 - Elsevier
Abstract Beta-cypermethrin (β-CYP) is a commonly used insecticide that is potentially toxic
and has adverse effects on the health of both animals and humans. Studies have indicated …

Morphokinetic parameters of mouse oocyte meiotic maturation and cumulus expansion are not affected by reproductive age or ploidy status

C Suebthawinkul, E Babayev, HC Lee… - Journal of Assisted …, 2023 - Springer
Introduction Morphokinetic analysis using a closed time-lapse monitoring system
(EmbryoScope+™) provides quantitative metrics of meiotic progression and cumulus …

[HTML][HTML] Three-Dimensionally Printed Agarose Micromold Supports Scaffold-Free Mouse Ex Vivo Follicle Growth, Ovulation, and Luteinization

EJ Zaniker, PH Hashim, S Gauthier, JA Ankrum… - Bioengineering, 2024 - mdpi.com
Ex vivo follicle growth is an essential tool, enabling interrogation of folliculogenesis,
ovulation, and luteinization. Though significant advancements have been made, existing …

Human follicular fluid elicits select dose- and age-dependent effects on mouse oocytes and cumulus–oocyte complexes in a heterologous in vitro maturation assay

SS Dipali, C Suebthawinkul, JE Burdette… - Molecular human …, 2023 - academic.oup.com
Follicular fluid (FF) is a primary microenvironment of the oocyte within an antral follicle.
Although several studies have defined the composition of human FF in normal physiology …

The severity of meiotic aneuploidy is associated with altered morphokinetic variables of mouse oocyte maturation

Y Zhu, CR Kratka, J Pea, HC Lee… - Human …, 2024 - academic.oup.com
STUDY QUESTION Is there an association between morphokinetic variables of meiotic
maturation and the severity of aneuploidy following in vitro maturation (IVM) in the mouse …

The effects of fructose on the developmental competence, biochemical biomarkers and apoptotic gene expression by murine oocytes

A Helmy, A Halawa, A Montaser… - Egyptian Journal of …, 2023 - ejvs.journals.ekb.eg
The goal of the current study was to investigate the effects of fructose supplementation in the
culture medium on in vitro maturation, and the developmental competence of murine …

[HTML][HTML] Combined Input Deep Learning Pipeline for Embryo Selection for In Vitro Fertilization Using Light Microscopic Images and Additional Features

K Onthuam, N Charnpinyo, K Suthicharoenpanich… - Journal of …, 2025 - mdpi.com
The current process of embryo selection in in vitro fertilization is based on morphological
criteria; embryos are manually evaluated by embryologists under subjective assessment. In …

Dynamic regulation of semaphorin 7A and adhesion receptors in ovarian follicle remodeling and ovulation

A Emery, KR Dunning, DT Dinh, LK Akison… - Frontiers in Cell and …, 2023 - frontiersin.org
The ovarian follicle is a complex structure that protects and helps in the maturation of the
oocyte, and then releases it through the controlled molecular and structural remodeling …

Oocyte Microscopic Image Fertilization Prediction based on First Polar Body Morphology using YOLOv8

T Sappakit, K Onthuam, T Limsila… - 2024 46th Annual …, 2024 - ieeexplore.ieee.org
The development of oocytes is crucial in the development and fertility of embryos in In Vitro
Fertilization (IVF). There are several internal and external factors that could affect the …