Survey on the recent advances in 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibition by diketone and triketone derivatives and congeneric compounds …

P Governa, G Bernardini, D Braconi… - Journal of Agricultural …, 2022 - ACS Publications
The serendipitous discovery of the HPPD inhibitors from allelopathic plants opened the way
for searching new and effective herbicidal agents by application of classical hit-to-lead …

Insights into 4-hydroxyphenylpyruvate dioxygenase-inhibitor interactions from comparative structural biology

HY Lin, J Dong, J Dong, WC Yang, GF Yang - Trends in Biochemical …, 2023 - cell.com
4-Hydroxyphenylpyruvate dioxygenase (HPPD) plays a key role in tyrosine metabolism and
has been identified as a promising target for herbicide and drug discovery. The structures of …

[HTML][HTML] Design of an HPPD fluorescent probe and visualization of plant responses to abiotic stress

X Zeng, Y Huang, J Dong, X Ma, JX Nan, W Chen… - Advanced …, 2022 - Elsevier
The upregulation of 4-hydroxyphenylpyruvate dioxygenase (HPPD) can protect plants from
adverse abiotic stress. Therefore, studying the changes of HPPD under abiotic stress is …

A Protocol for Activated Bioorthogonal Fluorescence Labeling and Imaging of 4‐Hydroxyphenylpyruvate Dioxygenase in Plants

X Zeng, X Ma, J Dong, B Li, S Hua Liu, J Yin… - Angewandte …, 2023 - Wiley Online Library
Hydroxyphenylpyruvate dioxygenase (HPPD) plays a crucial role in the synthesis of
nutrients needed to maintain optimal plant growth. Its level is closely linked to the extent of …

An artificially evolved gene for herbicide-resistant rice breeding

J Dong, XH Yu, J Dong, GH Wang, XL Wang… - Proceedings of the …, 2024 - pnas.org
Discovering and engineering herbicide-resistant genes is a crucial challenge in crop
breeding. This study focuses on the 4-hydroxyphenylpyruvate dioxygenase Inhibitor …

[HTML][HTML] Comparison of the binding interactions of 4-hydroxyphenylpyruvate dioxygenase inhibitor herbicides with humic acid: Insights from multispectroscopic …

P Chen, M Shi, X Liu, X Wang, M Fang, Z Guo… - Ecotoxicology and …, 2022 - Elsevier
Hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor is one of the important herbicides to
solve the problem of weed control. With the widespread and continued use of HPPD …

Pharmacophore-oriented discovery of novel 1, 2, 3-benzotriazine-4-one derivatives as potent 4-hydroxyphenylpyruvate dioxygenase inhibitors

YC Yan, W Wu, GY Huang, WC Yang… - Journal of Agricultural …, 2022 - ACS Publications
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a functional protein existing in almost all
aerobic organisms. In the field of agricultural chemicals, HPPD is acknowledged to be one of …

[HTML][HTML] Structural insights of 4-hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules

J Dong, J Dong, XH Yu, YC Yan, JX Nan, B He… - Advanced …, 2022 - Elsevier
Hydrophenylpyruvate dioxygenase (HPPD), a key enzyme involved in tyrosine catabolism,
has long been considered a promising target for herbicides and drugs. Several types of …

In vivo fluorescent screening for HPPD‐targeted herbicide discovery

YX Fu, ZY Zhang, WY Guo, YJ Dai… - Pest Management …, 2022 - Wiley Online Library
Abstract Background 4‐Hydroxyphenylpyruvate dioxygenase (HPPD), playing a critical role
in vitamin E and plastoquinone biosynthesis in plants, has been recognized as one of the …

Recent research progress and outlook in agricultural chemical discovery based on quinazoline scaffold

J Chen, Y Wang, X Luo, Y Chen - Pesticide Biochemistry and Physiology, 2022 - Elsevier
The discovery of new scaffolds and targets for pesticides is still a huge challenge facing the
sustainable development of modern agriculture. In recent years, quinazoline derivatives …