Towards a youth mental health paradigm: a perspective and roadmap
Most mental disorders have a typical onset between 12 and 25 years of age, highlighting the
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …
The normative modeling framework for computational psychiatry
Normative modeling is an emerging and innovative framework for mapping individual
differences at the level of a single subject or observation in relation to a reference model. It …
differences at the level of a single subject or observation in relation to a reference model. It …
[HTML][HTML] Brain charts for the human lifespan
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research
and clinical studies of the human brain. However, no reference standards currently exist to …
and clinical studies of the human brain. However, no reference standards currently exist to …
A canonical trajectory of executive function maturation from adolescence to adulthood
Theories of human neurobehavioral development suggest executive functions mature from
childhood through adolescence, underlying adolescent risk-taking and the emergence of …
childhood through adolescence, underlying adolescent risk-taking and the emergence of …
Charting brain growth and aging at high spatial precision
Defining reference models for population variation, and the ability to study individual
deviations is essential for understanding inter-individual variability and its relation to the …
deviations is essential for understanding inter-individual variability and its relation to the …
Resolving heterogeneity in schizophrenia through a novel systems approach to brain structure: individualized structural covariance network analysis
Reliable mapping of system-level individual differences is a critical first step toward
precision medicine for complex disorders such as schizophrenia. Disrupted structural …
precision medicine for complex disorders such as schizophrenia. Disrupted structural …
Individual variations in 'brain age'relate to early-life factors more than to longitudinal brain change
Brain age is a widely used index for quantifying individuals' brain health as deviation from a
normative brain aging trajectory. Higher-than-expected brain age is thought partially to …
normative brain aging trajectory. Higher-than-expected brain age is thought partially to …
Altered brain activity in unipolar depression unveiled using connectomics
Over 20 years of neuroimaging experiments into aberrant task-based brain activity in
unipolar depression have failed to reliably delineate a convergent set of anatomical regions …
unipolar depression have failed to reliably delineate a convergent set of anatomical regions …
Mind the gap: Performance metric evaluation in brain‐age prediction
Estimating age based on neuroimaging‐derived data has become a popular approach to
developing markers for brain integrity and health. While a variety of machine‐learning …
developing markers for brain integrity and health. While a variety of machine‐learning …
Heterogeneity is a hallmark of traumatic brain injury, not a limitation: a new perspective on study design in rehabilitation research
NV Covington, MC Duff - American journal of speech-language pathology, 2021 - ASHA
Purpose In both basic science and intervention research in traumatic brain injury (TBI),
heterogeneity in the patient population is frequently cited as a limitation and is often …
heterogeneity in the patient population is frequently cited as a limitation and is often …