In the last ten years, there has been a dramatic surge in the number of publications where
single or groups of cells are grown in substrata that have elements of basement membrane …

Epithelial tissues are the most rapidly dividing tissues in the body, holding a natural ability
for renewal and regeneration. This ability is crucial for survival as epithelia are essential to …

Stem cells support lifelong maintenance of adult organs, but their specific roles during injury
are poorly understood. Here we demonstrate that Lgr6 marks a regionally restricted …

Tissue repair is fundamental to our survival as tissues are challenged by recurrent damage.
During mammalian skin repair, cells respond by migrating and proliferating to close the …

Sertoli cells are the major component of the spermatogonial stem cell (SSC) niche; however,
regulatory mechanisms in Sertoli cells that dictate SSC fate decisions remain largely …

The secondary hair germ (SHG)—a transitory structure in the lower portion of the mouse
telogen hair follicle (HF)—is directly involved in anagen induction and eventual HF regrowth …

The liver and pancreas are critical organs maintaining whole body metabolism. Historically,
the expansion of adult-derived cells from these organs in vitro has proven challenging and …

Rotator cuff (RC) tears represent a large proportion of musculoskeletal injuries attended to at
the clinic and thereby make RC repair surgeries one of the most widely performed …

Stem cells have the remarkable ability to undergo proliferative symmetric divisions and self‐
renewing asymmetric divisions. Balancing of the two modes of division sustains tissue …

Bioregulatory systems medicine (BrSM) is a paradigm that aims to advance current medical
practices. The basic scientific and clinical tenets of this approach embrace an …