Cell alignment plays a critical role in various cell behaviors including cytoskeleton
reorganization, membrane protein relocation, nucleus gene expression, and ECM …

Mechanical forces play important roles in the regulation of various biological processes at
the molecular and cellular level, such as gene expression, adhesion, migration, and cell …

Vascular stiffness is a mechanical property of the vessel wall that affects blood pressure,
permeability, and inflammation. As a result, vascular stiffness is a key driver of (chronic) …

Brain tumor invasion leads to recurrence and resistance to treatment. Glioma cells invade in
distinct patterns, possibly determined by microenvironmental cues including chemokines …

Coronary plaque rupture is the most common cause of vessel thrombosis and acute
coronary syndrome. The accurate early detection of plaques prone to rupture may allow …

Shear stress, especially low shear stress (LowSS), plays an important role in vascular
remodeling during atherosclerosis. Endothelial cells (ECs), which are directly exposed to …

Multiple myeloma arises when malignant plasma cells invade and form multiple tumors in
the bone marrow. High levels of heparanase (HPSE) correlate with poor prognosis in …

String vessels are thin connective tissue strands, remnants of capillaries, with no endothelial
cells; they do not carry blood flow. They occur in numerous species, particularly in the …

Significance: Changes in shear stress associated with alterations in blood flow initiate a
signaling cascade that modulates the vascular phenotype. Shear stress is “sensed” by the …

The integrin lies at the center of our efforts to understand mechanotransduction in the human
body. Over the past two decades, a wealth of information has yielded important insights into …