Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …

After cardiovascular disease, cancer is the leading cause of death worldwide with
devastating health and economic consequences, particularly in developing countries. Inter …

Patient-derived organoids (PDOs) can model personalized therapy responses; however,
current screening technologies cannot reveal drug response mechanisms or how tumor …

The intestine serves as both our largest single barrier to the external environment and the
host of more immune cells than any other location in our bodies. Separating these potential …

Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or
adult tissue stem cells via a process of self-organization that results in the formation of organ …

Emerging evidence is revealing that alterations in gut microbiota are associated with
colorectal cancer (CRC). However, very little is currently known about whether and how gut …

In nature, cells reside in tissues subject to complex cell–cell interactions, signals from
extracellular molecules and niche soluble and mechanical signaling. These …

The organoids represent one of the greatest revolutions in the biomedical field in the past
decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly …

Induced pluripotent stem cells (iPSCs) enable the generation of previously unattainable,
scalable quantities of disease-relevant tissues from patients suffering from essentially any …

Intestinal organoids grown from adult stem cells have emerged as prototype 3D organotypic
models for studying tissue renewal and homeostasis. Owing to their strict dependence on …