Simple Summary L-asparaginase (L-ASNase) therapy is key for achieving the very high cure
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …

L-asparaginases (EC 3.5. 1.1) are a family of enzymes that catalyze the hydrolysis of L-
asparagine to L-aspartic acid and ammonia. These proteins with different biochemical …

L-asparaginase (L-ASNase) is a vital enzyme with a broad range of applications in medicine
and food industry. Drawbacks of current commercial L-ASNases stimulate the search for …

Abstract L-asparaginase (L-ASNase) is an enzyme that catalyzes the hydrolysis of L-
asparagine to L-aspartic acid and ammonia and is used to treat acute lymphoblastic …

L-asparaginases (L-ASNases, EC 3.5. 1.1) are a family of enzymes that are widely used for
the treatment of lymphoblastic leukemias. L-ASNase from Rhodospirillum rubrum (RrA) has …

Asparagine (Asn) and enzymes that catalyze the metabolism of Asn have been linked to the
regulation and propagation of colorectal cancer (CRC). Increased Asn and asparagine …

L-asparaginase (L-ASNase) is a biotechnologically relevant enzyme for the pharmaceutical,
biosensor and food industries. Efforts to discover new promising L-ASNases for different …

Amino acid deprivation therapy (AADT) is a promising strategy for developing novel
anticancer treatments, based on variations in metabolism of healthy and malignant cells. L …

Background: Amino acids are essential components in various biochemical pathways. The
deprivation of certain amino acids is an antimetabolite strategy for the treatment of amino …

The anticancer effect of L-asparaginases (L-ASNases) is attributable to their ability to
hydrolyze L-asparagine in the bloodstream and cancer cell microenvironment …