A teratoma is a benign tumor containing a mixture of differentiated tissues and organotypic
derivatives of the three germ layers, while a teratocarcinoma also contains embryonal …

Aim To establish an organotypic in vitro model of limb bud development to verify whether
epigenetic drug and teratogen 5-azacytidine (5azaC) has an effect on limb buds …

Antiepileptic/teratogen valproate (VPA) is a histone deacetylase inhibitor/epigenetic drug
proposed for the antitumor therapy where it is generally crucial to target poorly or …

Developmental processes in gastrulating rat embryos were investigated by using an
original, serum-free, chemically defined model system. 9.5-day-old rat embryos, without …

We screened for the impact of hyperthermal regimes varying in the cumulative equivalent
minutes at 43° C (CEM43° C) and media composition on tumour development using an …

Modified organ cultures of rat egg-cylinders were grown for 2weeks inEagle's minimal
essential medium (MEMI without serum. Differentiation of epidermis and cartilage in the …

In a unique serum-and protein-free chemically defined in vitro culture model of
postimplantation mammalian development the epidermis differentiates regularly, although …

Aim. To analyze neural tissue differentiation in a unique, chemically-defined in vitro culture
model of gastrulating rat embryo proper by use of transmission electron microscopy (TEM) …

Valproat (VPA), antiepileptički lijek/teratogen je također epigenetički inhibitor histonske
deacetilaze (HDACi). Cilj disertacije bio je istražiti aktivnost VPA na gastrulaciju sisavaca u …

Investigation of developmental potential of various embryonal tissues is important for design
of new approaches to regenerative medicine aimed at supplementing tissues damaged by …