Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While
the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL …

Abstract Interleukin-17A (IL-17A), the hallmark cytokine of the newly defined T helper 17
(TH17) cell subset, has important roles in protecting the host against extracellular …

There is compelling evidence that epithelial cells (ECs) at mucosal surfaces, beyond their
role in creating a physical barrier, are integral components of innate and adaptive immunity …

Since the discovery of interferons over 50 years ago, efforts to understand the biochemistry,
molecular biology and biological activities of cytokines have been intense and rewarding …

IL-17 is the defining cytokine of a newly-described “Th17” population that plays critical roles
in mediating inflammation and autoimmunity. The IL-17/IL-17 receptor superfamily is the …

Tumor necrosis factor (TNF) is an inflammatory cytokine that has important roles in various
immune responses, which are mediated through its two receptors, TNF receptor 1 (TNFR1) …

The role of T cell subpopulations in human disease is in a transition phase due to
continuous discovery of new subsets of T cell, one of which is Th17, characterized by the …

Abstract Interleukin 17 (IL-17)-producing helper T cells (TH-17 cells), together with their
effector cytokines, including members of the IL-17 family, are emerging as key mediators of …

Patients with acute kidney injury (AKI) frequently suffer from extra-renal complications
including hepatic dysfunction and systemic inflammation. We aimed to determine the …

The constituent polypeptides of the interleukin-17 family form six different homodimeric
cytokines (IL-17A–F) and the heterodimeric IL-17A/F. Their interactions with IL-17 receptors …