Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Acute kidney injury (AKI) is a major public health concern associated with high morbidity and
mortality. Despite decades of research, the pathogenesis of AKI remains incompletely …

Histone lysine crotonylation (Kcr), a novel posttranslational modification, is widespread as
acetylation (Kac); however, its roles are largely unknown. In this study, we report that histone …

Podocyte injury is a major determinant of proteinuric kidney disease and the identification of
potential therapeutic targets for preventing podocyte injury has clinical importance. Here, we …

Cells primarily rely on proteins to perform the majority of their physiological functions, and
the function of proteins is regulated by post‑translational modifications (PTMs). The …

Epigenetics refers to heritable changes in gene expression patterns not caused by an
altered nucleotide sequence, and includes non-coding RNAs and covalent modifications of …

Abstract Silent information regulator 1 (Sirt1) is a deacetylase, which plays an important role
in the occurrence and development of diabetic nephropathy (DN). Our previous study shows …

Histone deacetylase inhibitors (HDACi) have therapeutic effects in models of various renal
diseases including acute kidney injury (AKI); however, the underlying mechanism remains …

Background: Cancer is still the most common cause of morbidity in the world. Chitosan, a
commonly used natural polymer, is consisted of different molecular weight with different …

Cisplatin (CP) is an effective chemotherapeutic agent widely used in the treatment of various
solid tumours. However, CP nephrotoxicity is an important limitation for CP use; currently …