Investigating DNA supercoiling in eukaryotic genomes
Supercoiling is a fundamental property of DNA, generated by polymerases and other DNA-
binding proteins as a consequence of separating/bending the DNA double helix. DNA …
binding proteins as a consequence of separating/bending the DNA double helix. DNA …
PyContact: rapid, customizable, and visual analysis of noncovalent interactions in MD simulations
Molecular dynamics (MD) simulations have become ubiquitous in all areas of life sciences.
The size and model complexity of MD simulations are rapidly growing along with increasing …
The size and model complexity of MD simulations are rapidly growing along with increasing …
Remdesivir and ledipasvir among the FDA-approved antiviral drugs have potential to inhibit SARS-CoV-2 replication
The rapid spread of the virus, the surge in the number of deaths, and the unavailability of
specific SARS-CoV-2 drugs thus far necessitate the identification of drugs with anti-COVID …
specific SARS-CoV-2 drugs thus far necessitate the identification of drugs with anti-COVID …
Current genome editing tools in gene therapy: new approaches to treat cancer
O Shuvalov, A Petukhov, A Daks… - Current gene …, 2015 - ingentaconnect.com
Gene therapy suggests a promising approach to treat genetic diseases by applying genes
as pharmaceuticals. Cancer is a complex disease, which strongly depends on a particular …
as pharmaceuticals. Cancer is a complex disease, which strongly depends on a particular …
Molecular dynamics simulations of wild type and mutants of SAPAP in complexed with Shank3
L Piao, Z Chen, Q Li, R Liu, W Song, R Kong… - International journal of …, 2019 - mdpi.com
Specific interactions between scaffold protein SH3 and multiple ankyrin repeat domains
protein 3 (Shank3) and synapse-associated protein 90/postsynaptic density-95–associated …
protein 3 (Shank3) and synapse-associated protein 90/postsynaptic density-95–associated …
Direct observation of TALE protein dynamics reveals a two-state search mechanism
Transcription activator-like effector (TALE) proteins are a class of programmable DNA-
binding proteins for which the fundamental mechanisms governing the search process are …
binding proteins for which the fundamental mechanisms governing the search process are …
A TAL effector repeat architecture for frameshift binding
A Richter, J Streubel, C Blücher, B Szurek… - Nature …, 2014 - nature.com
Transcription activator-like effectors (TALEs) are important Xanthomonas virulence factors
that bind DNA via a unique tandem 34-amino-acid repeat domain to induce expression of …
that bind DNA via a unique tandem 34-amino-acid repeat domain to induce expression of …
Repeat 1 of TAL effectors affects target specificity for the base at position zero
T Schreiber, U Bonas - Nucleic acids research, 2014 - academic.oup.com
AvrBs3, the founding member of the Xanthomonas transcription-activator-like effectors
(TALEs), is translocated into the plant cell where it localizes to the nucleus and acts as …
(TALEs), is translocated into the plant cell where it localizes to the nucleus and acts as …
Molecular dynamics simulation study reveals potential substrate entry path into γ-secretase/presenilin-1
Abstract Presenilin 1 (PS1) is the catalytic unit of γ-secretase which cleaves more than one
hundred substrates. Among them, amyloid precursor protein (APP) and Notch are notable …
hundred substrates. Among them, amyloid precursor protein (APP) and Notch are notable …
Cross Dimerization of Amyloid-β and αSynuclein Proteins in Aqueous Environment: A Molecular Dynamics Simulations Study
JC Jose, P Chatterjee, N Sengupta - PloS one, 2014 - journals.plos.org
Self-assembly of the intrinsically unstructured proteins, amyloid beta (A β) and alpha
synclein (αSyn), are associated with Alzheimer's Disease, and Parkinson's and Lewy Body …
synclein (αSyn), are associated with Alzheimer's Disease, and Parkinson's and Lewy Body …