The blood–brain barrier (BBB) is a dynamic and complex interface between blood and the
central nervous system that strictly controls the exchanges between the blood and brain …

The blood–brain barrier (BBB) is a highly specialized system that controls the exchanges
between the blood and the central nervous system (CNS). This barrier shields the CNS from …

The blood–brain barrier (BBB) is a major obstacle for drug delivery to the brain. To seek for
in vitro BBB models that are more accessible than animals for investigating drug transport …

In evaluating drugs that enter or are excluded from the brain, novel pharmaceutical
strategies are needed. For this reason, we have developed a humanized Dynamic In vitro …

The role of astrocytes is becoming increasingly important to understanding how
glioblastoma (GBM) tumor cells diffusely invade the brain. Yet, little is known of the …

A variety of therapeutic proteins have shown potential to treat central nervous system (CNS)
disorders. Challenge to deliver these protein molecules to the brain is well known. Proteins …

In addition to malignant cancer cells, tumors contain a variety of different stromal cells that
constitute the tumor microenvironment. Some of these cell types provide crucial support for …

Diseases that affect the Central Nervous System (CNS) are one of the most exciting
challenges of recent years, as they are ubiquitous and affect all ages. Although these …

Brain metastases are one of the most difficult malignancies to treat owing to their location
and mostly multifocal and infiltrative growth. Chemotherapy, which is often effective against …

Brain microvessels possess barrier structures comprising tight junctions which are critical for
the maintenance of central nervous system homeostasis. Brain vascular diseases, such as …