Type 1 diabetes mellitus (T1DM) is a chronic immune-mediated disease with a subclinical
prodromal period, characterized by selective loss of insulin-producing-β cells in the …

Environmental DNA sequencing has revealed the expansive biodiversity of microorganisms
and clarified the relationship between host-associated microbial communities and host …

Discriminative neural networks offer little or no performance guarantees when deployed on
data not generated by the same process as the training distribution. On such out-of …

Plasmids are mobile genetics elements that play an important role in the environmental
adaptation of microorganisms. Although plasmids are usually analyzed in cultured …

Large-scale recovery of genomes from isolates, single cells, and metagenomic data has
been made possible by advances in computational methods and substantial reductions in …

Background The problem of supervised DNA sequence classification arises in several fields
of computational molecular biology. Although this problem has been extensively studied, it is …

Metagenomic shotgun sequencing data can identify microbes populating a microbial
community and their proportions, but existing taxonomic profiling methods are inefficient for …

Determining the taxonomic affiliation of sequences assembled from metagenomes remains
a major bottleneck that affects research across the fields of environmental, clinical and …

Like all organisms on the planet, environmental microbes are subject to the forces of
molecular evolution. Metagenomic sequencing provides a means to access the DNA …

Recent findings have demonstrated that the gut microbiome complements our human
genome with at least 100-fold more genes. In contrast to our Homo sapiens–derived genes …