The evolution of glucagon has seen the transition from an impurity in the preparation of
insulin to the development of glucagon receptor agonists for use in type 1 diabetes. In type 2 …

Ghrelin, an endogenous brain–gut peptide, is secreted in large quantities, mainly from the
stomach, in humans and rodents. It can perform the biological function of activating the …

Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In
contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening …

Ghrelin administration induces food intake and body weight gain. Based on these actions,
the ghrelin system was initially proposed as an antiobesity target. Subsequent studies using …

Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here,
we sought to determine whether ghrelin's effects on islets extend to the alteration of islet size …

Much effort has been directed at studying the orexigenic actions of administered ghrelin and
the potential effects of the endogenous ghrelin system on food intake, food reward, body …

Metabolic-associated steatotic liver disease (MASLD) is closely associated with obesity.
MASLD affects over 1 billion adults globally but there are few treatment options available …

Background The hormone ghrelin stimulates food intake, promotes adiposity, increases
body weight, and elevates blood glucose. Consequently, alterations in plasma ghrelin levels …

Type 1 diabetes is characterized by selective loss of beta cells and insulin secretion, which
significantly impact glucose homeostasis. However, this progressive disease is also …

The main goal of therapeutic management of type 1 Diabetes Mellitus (T1DM) is to maintain
optimal glycemic control to prevent acute and long-term diabetes complications and to …