Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐and aging‐related diseases

AG Panossian, T Efferth, AN Shikov… - Medicinal research …, 2021 - Wiley Online Library
Adaptogens comprise a category of herbal medicinal and nutritional products promoting
adaptability, resilience, and survival of living organisms in stress. The aim of this review was …

Ginseng compounds: an update on their molecular mechanisms and medical applications

JM Lu, Q Yao, C Chen - Current vascular pharmacology, 2009 - ingentaconnect.com
Ginseng is one of the most widely used herbal medicines and is reported to have a wide
range of therapeutic and pharmacological applications. Ginsenosides, the major …

[HTML][HTML] Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions

P Mohanan, S Subramaniyam, R Mathiyalagan… - Journal of Ginseng …, 2018 - Elsevier
Ginseng has gained its popularity as an adaptogen since ancient days because of its
triterpenoid saponins, known as ginsenosides. These triterpenoid saponins are unique and …

Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals

A Panossian - Annals of the New York Academy of Sciences, 2017 - Wiley Online Library
Adaptogens are stress‐response modifiers that increase an organism's nonspecific
resistance to stress by increasing its ability to adapt and survive. The classical reductionist …

[HTML][HTML] Adaptogenic effects of Panax ginseng on modulation of cardiovascular functions

M Irfan, YS Kwak, CK Han, SH Hyun… - Journal of Ginseng …, 2020 - Elsevier
Cardiovascular diseases are a rapidly growing epidemic with high morbidity and mortality.
There is an urgent need to develop nutraceutical-based therapy with minimum side effects to …

Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor‐dependent osteoblastic functions in UMR 106 cells

SK Mok, WF Chen, WP Lai, PC Leung… - British journal of …, 2010 - Wiley Online Library
Background and purpose: Icariin may be the active ingredient in Herba Epimedii, a Chinese
herb commonly used for treatment of osteoporosis. The present study aims to delineate the …

Estrogenic terpenes and terpenoids: Pathways, functions and applications

R Kiyama - European Journal of Pharmacology, 2017 - Elsevier
Terpenes are made of the isoprene unit (C 5), and along with their derivatives, terpenoids,
they are widely distributed in plants as active ingredients involved in anti-inflammation, anti …

Zearalenone promotes cell proliferation or causes cell death?

W Zheng, B Wang, X Li, T Wang, H Zou, J Gu, Y Yuan… - Toxins, 2018 - mdpi.com
Zearalenone (ZEA), one of the mycotoxins, exerts different mechanisms of toxicity in different
cell types at different doses. It can not only stimulate cell proliferation but also inhibit cell …

Effect of fermented Panax ginseng extract (GINST) on oxidative stress and antioxidant activities in major organs of aged rats

T Ramesh, SW Kim, JH Sung, SY Hwang… - Experimental …, 2012 - Elsevier
The intracellular levels of oxidant and antioxidant balances are gradually distorted during
the aging process. An age associated elevation of oxidative stress occurring throughout the …

Naringin improves bone properties in ovariectomized mice and exerts oestrogen‐like activities in rat osteoblast‐like (UMR‐106) cells

WY Pang, XL Wang, SK Mok, WP Lai… - British journal of …, 2010 - Wiley Online Library
Background and purpose: Naringin, a flavanone glycoside in citrus fruits, has been recently
reported to stimulate bone formation in vitro and in vivo. The present study was designed to …