Hepatic fibrosis is a major cause of morbidity and mortality worldwide, as it ultimately leads
to cirrhosis, which is estimated to affect up to 2% of the global population. Hepatic fibrosis is …

Nutrients are required for growth and survival of all cells, but are also crucially involved in
cell fate determination of many cell types, including immune cells. There is a growing …

Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and
evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the …

Dendritic cells (DCs) are antigen-presenting cells that bridge innate and adaptive immune
responses. Multiple cell types, including DCs, rely on cellular metabolism to determine their …

AIM To understand the underlying metabolic changes in human liver disease we have
applied nuclear magnetic resonance (NMR) metabolomics analysis to human liver tissue …

Background The liver plays a key role in amino acid metabolism. In former studies, a ratio
between branched-chain and aromatic amino acids (Fischer's ratio) revealed associations …

Background & Aims Severe forms of alcohol-related liver disease are associated with
increased susceptibility to infections which are associated with poor prognosis. The cellular …

Immunity and metabolism are interdependent and coordinated, which are the core
mechanisms for the body to maintain homeostasis. In tumor immunology research …

Background Metabolic disorders are important pathophysiologies that can cause multiple
organ dysfunction and worsen prognosis in Fontan patients. This study aimed to …

Abstract Background & Aims Hepatitis C virus (HCV), human immunodeficiency virus (HIV)
and cirrhosis induce metabolic disorders. Here, we aimed to evaluate the association of …