Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …

Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …

Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide-binding (G)
proteins, including the ARF-like (ARL) proteins and SAR1, regulate membrane traffic and …

There is now considerable and increasing evidence for a causal role for aberrant activity of
the Ras superfamily of small GTPases in human cancers. These GTPases function as GDP …

Protein traffic is necessary to maintain homeostasis in all eukaryotic organisms. All newly
synthesized secretory proteins destined to the secretory and endolysosmal systems are …

Cilia are microtubule‐based, cell‐surface projections whose machinery is evolutionarily
conserved. In vertebrates, cilia are observed on almost every cell type and are either motile …

ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss of Arl13b disrupts
cilia architecture, protein trafficking and Sonic hedgehog signaling. To determine whether …

The GIT proteins, GIT1 and GIT2, are GTPase-activating proteins (inactivators) for the ADP-
ribosylation factor (Arf) small GTP-binding proteins, and function to limit the activity of Arf …

Two small GTPases, Rab and Arf, are well-known molecular switches that function in diverse
membrane-trafficking routes in a coordinated manner; however, very little is known about the …

The GTPase Arl13b participates in ciliary protein transport, but its contribution to
intraflagellar transport (IFT), the main motor-based protein shuttle of cilia, remains largely …