Rheumatoid Arthritis — Common Origins, Divergent Mechanisms | New England Journal of
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Rheumatoid arthritis (RA) is characterized by inflammation and destruction of bone and
cartilage in affected joints. Autoimmune responses lead to increased osteoclastic bone …

Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation
and destruction. There is currently no cure for rheumatoid arthritis, and the effectiveness of …

Mononuclear phagocytes (MNPs) encompass dendritic cells, monocytes, and macrophages
(MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We …

Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

Ferroptosis is a nonapoptotic cell death process that requires cellular iron and the
accumulation of lipid peroxides. In progressive rheumatoid arthritis (RA), synovial fibroblasts …

Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …

Fibroblasts are important cells for the support of homeostatic tissue function. In inflammatory
diseases such as rheumatoid arthritis and inflammatory bowel disease, fibroblasts take on …

Ulcerative colitis and Crohn's disease are chronic inflammatory intestinal diseases with
perplexing heterogeneity in disease manifestation and response to treatment. While the …

Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are
unknown. We hypothesized that synovial tissue macrophages (STM), which persist in …