Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Studies of bioactive lipids in general and sphingolipids in particular have intensified over the
past several years, revealing an unprecedented and unanticipated complexity of the …

Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide,
which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS …

Dyslipidaemia is a hallmark of chronic kidney disease (CKD). The severity of dyslipidaemia
not only correlates with CKD stage but is also associated with CKD-associated …

Long-chain omega-3 fatty acids belong to a family of polyunsaturated fatty acids that are
known to have important beneficial effects on metabolism and inflammation. Such effects …

Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable
proportion of the human population and severely compromise quality of life. Therefore …

Amitriptyline, a tricyclic antidepressant, has been used in the clinic to treat a number of
disorders, in particular major depression and neuropathic pain. In the 1970s the ability of …

Lipid metabolites regulate fatty acid and glucose homeostasis. The intention of the current
study is to identify circulating lipid species, which are altered in rodent obesity and strongly …

Nutrient oversupply associated with a high fat diet (HFD) significantly alters cellular
metabolism, and specifically including sphingolipid metabolism. Sphingolipids are emerging …

AMP-activated protein kinase (AMPK) is suppressed in diabetes and may be due to a high
ATP/AMP ratio, however the quantitation of nucleotides in vivo has been extremely difficult …