Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine

I Dakilah, A Harb, E Abu-Gharbieh… - Frontiers in …, 2024 - frontiersin.org
The global burden of cancer continues to rise, underscoring the urgency of developing more
effective and precisely targeted therapies. This comprehensive review explores the …

Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia—the possibility to target several kinases through inhibition …

AK Brenner, H Reikvam, A Lavecchia, Ø Bruserud - Molecules, 2014 - mdpi.com
The cell division cycle 25 (CDC25) phosphatases include CDC25A, CDC25B and CDC25C.
These three molecules are important regulators of several steps in the cell cycle, including …

Olive (Olea europaea) Leaf Extract Induces Apoptosis and Monocyte/Macrophage Differentiation in Human Chronic Myelogenous Leukemia K562 Cells: Insight into …

I Samet, J Han, L Jlaiel, S Sayadi… - Oxidative medicine and …, 2014 - Wiley Online Library
Differentiation therapy is an attractive approach aiming at reversing malignancy and
reactivating endogenous differentiation programs in cancer cells. Olive leaf extract, known …

Mechanisms of endocrinology: Cell cycle regulation in adrenocortical carcinoma

SS Pereira, MP Monteiro, I Bourdeau… - European Journal of …, 2018 - academic.oup.com
Adrenocortical carcinomas (ACCs) are rather rare endocrine tumors that often have a poor
prognosis. The reduced survival rate associated with these tumors is due to their aggressive …

Link of zygotic genome activation and cell cycle control

B Liu, J Grosshans - Zygotic Genome Activation: Methods and Protocols, 2017 - Springer
The activation of the zygotic genome and onset of transcription in blastula embryos is linked
to changes in cell behavior and remodeling of the cell cycle and constitutes a transition from …

Beneficial Effect of Olive Oil and Its Derivates: Focus on Hematological Neoplasm

C Campo, S Gangemi, G Pioggia, A Allegra - Life, 2024 - mdpi.com
Olive oil (Olea europaea) is one of the major components of the Mediterranean diet and is
composed of a greater percentage of monounsaturated fatty acids, such as oleic acid; …

Phosphorylation of CDC25A on SER283 in late S/G2 by CDK/cyclin complexes accelerates mitotic entry

L Mazzolini, A Broban, C Froment, O Burlet-Schiltz… - Cell Cycle, 2016 - Taylor & Francis
The Cdc25A phosphatase is an essential activator of CDK-cyclin complexes at all steps of
the eukaryotic cell cycle. The activity of Cdc25A is itself regulated in part by positive and …

Doxorubicin combined with phytochemicals as pro-apoptotic agents and protein kinase inhibitors for the treatment of acute myeloid leukaemia

U Osemeke - 2020 - repository.mdx.ac.uk
Acute myeloid leukaemia is one of the most common form of adult leukaemia with several
kinase mutations. The FLT3-ITD mutation is a common kinase mutation observed in (20 …

[PDF][PDF] Cloning and Expression Analysis of Cdc25 Gene of Sipunculus nudus in Oocytes

Y Su, J Ye, Q Liu, Y Zeng, C Zhang… - International Journal of …, 2020 - academia.edu
Abstract Cell division cycle 25 (Cdc25) is an important dual specificity phosphatase, which
plays an important role in regulating the process of oocytes meiosis and embryo …

[PDF][PDF] A Boolean Modeling Approach to Understanding Synergies Between Cell Phenotypes in Early Neurogenesis

NR Sundheimer - 2017 - openworks.wooster.edu
Neuronal development is an investigation that has yet to be fully understood. Different
transcription factors and markers are expressed differently throughout the developmental …