Therapeutic mechanisms of psychedelics and entactogens
BD Heifets, DE Olson - Neuropsychopharmacology, 2024 - nature.com
Recent clinical and preclinical evidence suggests that psychedelics and entactogens may
produce both rapid and sustained therapeutic effects across several indications. Currently …
produce both rapid and sustained therapeutic effects across several indications. Currently …
MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial
This multi-site, randomized, double-blind, confirmatory phase 3 study evaluated the efficacy
and safety of 3, 4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) versus …
and safety of 3, 4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) versus …
Vesicular monoamine transporter (VMAT) regional expression and roles in pathological conditions
M Alwindi, A Bizanti - Heliyon, 2023 - cell.com
Vesicular monoamine transporters (VMATs) are key regulators of neurotransmitter release
responsible for controlling numerous physiological, cognitive, emotional, and behavioral …
responsible for controlling numerous physiological, cognitive, emotional, and behavioral …
Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors
The presynaptic serotonin transporter (SERT) clears extracellular serotonin following
vesicular release to ensure temporal and spatial regulation of serotonergic signalling and …
vesicular release to ensure temporal and spatial regulation of serotonergic signalling and …
Dynamics of human serotonin synthesis differentially link to reward anticipation and feedback
Abstract Serotonin (5-HT) plays an essential role in reward processing, however, the
possibilities to investigate 5-HT action in humans during emotional stimulation are …
possibilities to investigate 5-HT action in humans during emotional stimulation are …
Direct serotonin release in humans shapes aversive learning and inhibition
MJ Colwell, H Tagomori, F Shang, HI Cheng… - Nature …, 2024 - nature.com
The role of serotonin in human behaviour is informed by approaches which allow in vivo
modification of synaptic serotonin. However, characterising the effects of increased …
modification of synaptic serotonin. However, characterising the effects of increased …
Structure–Activity Relationship of Synthetic Cathinones: An Updated Review
The escalating prevalence of new psychoactive substances (NPSs) poses a significant
public health challenge, evidenced by the vast chemical diversity, with over 500 substances …
public health challenge, evidenced by the vast chemical diversity, with over 500 substances …
[HTML][HTML] Kappa opioid receptor antagonism rescues genetic perturbation of dopamine homeostasis: Molecular, physiological and behavioral consequences
Aberrant dopamine (DA) signaling is implicated in schizophrenia, bipolar disorder (BPD),
autism spectrum disorder (ASD), substance use disorder, and attention-deficit/hyperactivity …
autism spectrum disorder (ASD), substance use disorder, and attention-deficit/hyperactivity …
Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties
P Puigseslloses, N Nadal-Gratacós, G Ketsela… - Molecular …, 2024 - nature.com
Recent studies have sparked renewed interest in the therapeutic potential of psychedelics
for treating depression and other mental health conditions. Simultaneously, the novel …
for treating depression and other mental health conditions. Simultaneously, the novel …
Novel Benzofuran Derivatives Induce Monoamine Release and Substitute for the Discriminative Stimulus Effects of 3, 4-Methylenedioxymethamphetamine
CB Johnson, D Walther, MJ Baggott, LE Baker… - The Journal of …, 2024 - Elsevier
Methylenedioxymethamphetamine (MDMA) has shown efficacy as a medication adjunct for
treating post-traumatic stress disorder (PTSD). However, MDMA is also used in nonmedical …
treating post-traumatic stress disorder (PTSD). However, MDMA is also used in nonmedical …