Tumor angiogenesis is necessary for the continued survival and development of tumor cells,
and plays an important role in their growth, invasion, and metastasis. The tumor …

The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease with
diverse drivers of disease progression and mechanisms of therapeutic resistance. We …

Both hereditary and sporadic breast cancer are suggested to develop from a stem cell
subcomponent retaining most key stem cell properties but with dysregulation of self-renewal …

Endothelial cells are a constitutive part of the heart and vasculature and form a crucial link
between the cardiovascular system and the immune system. Besides their commonly …

Abstract Interleukin-8 (IL-8) is a proinflammatory CXC chemokine associated with the
promotion of neutrophil chemotaxis and degranulation. This chemokine activates multiple …

The consequences of prostate cancer metastasis remain severe, with huge impact on the
mortality and overall quality of life of affected patients. Despite the convoluted interplay and …

IL-8, a member of the chemokine family, has been shown to play an important role in tumor
growth, angiogenesis, and metastasis. The objective of this study was to determine the …

Tumors may be initiated and maintained by a cellular subcomponent that displays stem cell
properties. We have used the expression of aldehyde dehydrogenase as assessed by the …

Recent evidence suggests that breast cancer and other solid tumors possess a rare
population of cells capable of extensive self-renewal that contribute to metastasis and …