New insights into the evasion of host innate immunity by Mycobacterium tuberculosis
Q Chai, L Wang, CH Liu, B Ge - Cellular & molecular immunology, 2020 - nature.com
Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that
causes tuberculosis (TB), which remains the leading infectious cause of human death. The …
causes tuberculosis (TB), which remains the leading infectious cause of human death. The …
The exploitation of host autophagy and ubiquitin machinery by Mycobacterium tuberculosis in shaping immune responses and host defense during infection
Intracellular pathogens have evolved various efficient molecular armaments to subvert
innate defenses. Cellular ubiquitination, a normal physiological process to maintain …
innate defenses. Cellular ubiquitination, a normal physiological process to maintain …
Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system
Mycobacterium tuberculosis PtpA, a secreted tyrosine phosphatase essential for
tuberculosis pathogenicity, could be an ideal target for a drug against tuberculosis, but its …
tuberculosis pathogenicity, could be an ideal target for a drug against tuberculosis, but its …
Zooming in on common immune evasion mechanisms of pathogens in phagolysosomes: potential broad-spectrum therapeutic targets against infectious diseases
The intracellular viral, bacterial, or parasitic pathogens evade the host immune challenges to
propagate and cause fatal diseases. The microbes overpower host immunity at various …
propagate and cause fatal diseases. The microbes overpower host immunity at various …
Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted
Mixed lineage kinase domain-like (MLKL)-dependent necroptosis is thought to be implicated
in the death of mycobacteria-infected macrophages, reportedly allowing escape and …
in the death of mycobacteria-infected macrophages, reportedly allowing escape and …
Coxiella burnetii Inhibits Apoptosis in Human THP-1 Cells and Monkey Primary Alveolar Macrophages
DE Voth, D Howe, RA Heinzen - Infection and immunity, 2007 - Am Soc Microbiol
Coxiella burnetii, the cause of human Q fever, is an aerosol-borne, obligate intracellular
bacterium that targets host alveolar mononuclear phagocytic cells during infection. In all cell …
bacterium that targets host alveolar mononuclear phagocytic cells during infection. In all cell …
Inhibition of Nuclear Factor-Kappa B Activation Decreases Survival of Mycobacterium tuberculosis in Human Macrophages
X Bai, NE Feldman, K Chmura, AR Ovrutsky, WL Su… - PloS one, 2013 - journals.plos.org
Nuclear factor-kappa B (NFκB) is a ubiquitous transcription factor that mediates pro-
inflammatory responses required for host control of many microbial pathogens; on the other …
inflammatory responses required for host control of many microbial pathogens; on the other …
NF-κB activation controls phagolysosome fusion-mediated killing of mycobacteria by macrophages
Macrophages can potentially kill all mycobacteria by poorly understood mechanisms. In this
study, we explore the role of NF-κB in the innate immune response of macrophages against …
study, we explore the role of NF-κB in the innate immune response of macrophages against …
Living on the Edge: Inhibition of Host Cell Apoptosis by Mycobacterium Tuberculosis
V Briken, JL Miller - Future microbiology, 2008 - Taylor & Francis
Tuberculosis is a human disease of global importance caused by infection with
Mycobacterium tuberculosis. Thus, an estimated one-third of the world's population is …
Mycobacterium tuberculosis. Thus, an estimated one-third of the world's population is …
The Balance of Apoptotic and Necrotic Cell Death in Mycobacterium tuberculosis Infected Macrophages Is Not Dependent on Bacterial Virulence
Background An important mechanism of Mycobacterium tuberculosis pathogenesis is the
ability to control cell death pathways in infected macrophages: apoptotic cell death is …
ability to control cell death pathways in infected macrophages: apoptotic cell death is …