Impact of a defunctioning ileostomy and time to stoma closure on bowel function after low anterior resection for rectal cancer: a systematic review and meta-analysis

I Vogel, N Reeves, PJ Tanis, WA Bemelman… - Techniques in …, 2021 - Springer
Background Impaired bowel function after low anterior resection (LAR) for rectal cancer is a
frequent problem with a major impact on quality of life. The aim of this study was to assess …

[HTML][HTML] Gut microbial metabolome in inflammatory bowel disease: From association to therapeutic perspectives

M Li, L Yang, C Mu, Y Sun, Y Gu, D Chen, T Liu… - Computational and …, 2022 - Elsevier
Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis
(UC), is a set of clinically chronic, relapsing gastrointestinal inflammatory disease and lacks …

Functional outcomes from a randomized trial of early closure of temporary ileostomy after rectal excision for cancer

C Keane, J Park, S Öberg, A Wedin… - Journal of British …, 2019 - academic.oup.com
Background Low anterior resection syndrome (LARS) has a significant impact on
postoperative quality of life. Although early closure of an ileostomy is safe in selected …

[HTML][HTML] Diversion colitis and pouchitis: a mini-review

K Tominaga, K Kamimura, K Takahashi… - World Journal of …, 2018 - ncbi.nlm.nih.gov
Diversion colitis is characterized by inflammation of the mucosa in the defunctioned segment
of the colon after colostomy or ileostomy. Similar to diversion colitis, diversion pouchitis is an …

IRAK-M expression in tumor cells supports colorectal cancer progression through reduction of antimicrobial defense and stabilization of STAT3

R Kesselring, J Glaesner, A Hiergeist, E Naschberger… - Cancer cell, 2016 - cell.com
Colorectal cancer (CRC) is associated with loss of epithelial barrier integrity, which
facilitates the interaction of the immunological microenvironment with the luminal …

Does a defunctioning stoma impair anorectal function after low anterior resection of the rectum for cancer? A 12-year follow-up of a randomized multicenter trial

S Gadan, H Floodeen, R Lindgren… - Diseases of the Colon …, 2017 - journals.lww.com
BACKGROUND: Anorectal function after low anterior resection of the rectum for cancer is
often impaired, and long-term outcome has not frequently been reported. OBJECTIVE: We …

Early vs. standard reversal ileostomy: a systematic review and meta-analysis

NJ O'Sullivan, HC Temperley, TS Nugent… - Techniques in …, 2022 - Springer
Background Formation of a defunctioning loop ileostomy is common after mid and low rectal
resection. Historically, they were reversed between 3 and 6 months after initial resection …

Low anterior resection syndrome: predisposing factors and treatment

R Garfinkle, M Boutros - Surgical oncology, 2022 - Elsevier
Bowel dysfunction after restorative proctectomy, commonly referred to as Low Anterior
Resection Syndrome (LARS), is a common long-term sequela of rectal cancer treatment that …

The gut microbiota in liver transplantation recipients during the perioperative period

Z Lai, Z Chen, A Zhang, Z Niu, M Cheng… - Frontiers in …, 2022 - frontiersin.org
Background: Chronic liver disease is a global problem, and an increasing number of
patients receive a liver transplant yearly. The characteristics of intestinal microbial …

[HTML][HTML] Evaluation of intestinal microbiota, short-chain fatty acids, and immunoglobulin a in diversion colitis

K Tominaga, A Tsuchiya, T Mizusawa… - … and Biophysics Reports, 2021 - Elsevier
It is reported that an increase in aerobic bacteria, a lack of short-chain fatty acids (SCFAs),
and immune disorders in the diverted colon are major causes of diversion colitis. However …