Organoids: The current status and biomedical applications

S Yang, H Hu, H Kung, R Zou, Y Dai, Y Hu… - MedComm, 2023 - Wiley Online Library
Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

Modularized microrobot with lock-and-detachable modules for targeted cell delivery in bile duct

L Su, D Jin, Y Wang, Q Wang, C Pan, S Jiang… - Science …, 2023 - science.org
The magnetic microrobots promise benefits in minimally invasive cell-based therapy.
However, they generally suffer from an inevitable compromise between their magnetic …

Cell therapy in end-stage liver disease: replace and remodel

XH Hu, L Chen, H Wu, YB Tang, QM Zheng… - Stem Cell Research & …, 2023 - Springer
Liver disease is prevalent worldwide. When it reaches the end stage, mortality rises to 50%
or more. Although liver transplantation has emerged as the most efficient treatment for end …

[HTML][HTML] Bavachinin protects the liver in NAFLD by promoting regeneration via targeting PCNA

X Dong, S Lu, Y Tian, H Ma, Y Wang, X Zhang… - Journal of Advanced …, 2024 - Elsevier
Introduction Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease all
over the world, and no drug is approved for the treatment of NAFLD. Bavachinin (BVC) is …

[HTML][HTML] Human chemically-derived hepatic progenitors (hCdHs) as a source of liver organoid generation: application in regenerative medicine, disease modeling …

S Salas-Silva, Y Kim, TH Kim, M Kim, D Seo, J Choi… - Biomaterials, 2023 - Elsevier
Background & aims Several types of human stem cells from embryonic (ESCs) and induced
pluripotent (iPSCs) to adult tissue-specific stem cells are commonly used to generate 3D …

A Unification of Nanotopography and Extracellular Matrix in Electrospun Scaffolds for Bioengineered Hepatic Models

Y Gao, TSR Bate, A Callanan - Acs Applied Bio Materials, 2023 - ACS Publications
Donor liver shortage is a crucial global public health problem as whole-organ
transplantation is the only definitive cure for liver disease. Liver tissue engineering aims to …

Design and batch fabrication of anisotropic microparticles toward small-scale robots using microfluidics: recent advances

C Yang, X Liu, X Song, L Zhang - Lab on a Chip, 2024 - pubs.rsc.org
Small-scale robots with shape anisotropy have garnered significant scientific interest due to
their enhanced mobility and precise control in recent years. Traditionally, these miniature …

Long-term ex situ normothermic machine perfusion allows regeneration of human livers with severe bile duct injury

M Ly, NS Lau, C Dennis, J Chen, C Risbey… - American Journal of …, 2024 - Elsevier
Bile duct regeneration is hypothesized to prevent biliary strictures, a leading cause of
morbidity after liver transplantation. Assessing the capacity for biliary regeneration may …

Scalable production of size-controlled cholangiocyte and cholangiocarcinoma organoids within liver extracellular matrix-containing microcapsules

GS van Tienderen, J Willemse, B van Loo… - Cells, 2022 - mdpi.com
Advances in biomaterials, particularly in combination with encapsulation strategies, have
provided excellent opportunities to increase reproducibility and standardization for cell …

Multiple facets of cellular homeostasis and regeneration of the mammalian liver

SS Huppert, RE Schwartz - Annual review of physiology, 2023 - annualreviews.org
Liver regeneration occurs in response to diverse injuries and is capable of functionally
reestablishing the lost parenchyma. This phenomenon has been known since antiquity …