MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary
target mRNAs and repress their expression. Precursor miRNA molecules undergo nuclear …

MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and
overexpression of individual'oncomiRs' or genetic loss of tumour suppressor miRNAs are …

Kidney tumours are among the most common solid tumours in children, comprising distinct
subtypes differing in many aspects, including cell-of-origin, genetics, and pathology. Pre …

Pathogenic germline DICER1 variants cause a hereditary cancer predisposition syndrome
with a variety of manifestations. In addition to conferring increased cancer risks for …

We performed genome-wide sequencing and analyzed mRNA and miRNA expression, DNA
copy number, and DNA methylation in 117 Wilms tumors, followed by targeted sequencing …

Abstract DICER1 syndrome (OMIM 606241, 601200) is a rare autosomal dominant familial
tumor predisposition disorder with a heterozygous DICER1 germline mutation. The most …

Dicer is central to microRNA-mediated silencing and several other RNA interference
phenomena that are profoundly embedded in cancer gene networks. Most recently, both …

Blastemal histology in chemotherapy-treated pediatric Wilms tumors (nephroblastoma) is
associated with adverse prognosis. To uncover the underlying tumor biology and find …

We report the most common single-nucleotide substitution/deletion mutations in favorable
histology Wilms tumors (FHWTs) to occur within SIX1/2 (7% of 534 tumors) and microRNA …

MicroRNAs (miRNAs) are integral to the gene regulatory network. A single miRNA is
capable of controlling the expression of hundreds of protein coding genes and modulate a …