Antigen presentation by both classical MHC class II molecules and the non-classical MHC
class I-like molecule CD1D requires their entry into the endosomal/lysosomal compartment …

The endosomal pathway of antigen presentation leads to the display of peptides on major
histocompatibility complex (MHC) class II molecules at the cell surface of antigen‐presenting …

Degradation of invariant chain (Ii) is a critical step in major histocompatibility complex class II–
restricted antigen presentation. Cathepsin L was found to be necessary for Ii degradation in …

Human leukocyte antigen DM (HLA-DM) molecules are structurally related to classical MHC
class II molecules and reside in the lysosomallke compartment where class II-restricted …

Destruction of Ii by proteolysis is required for MHC class II molecules to bind antigenic
peptides, and for transport of the resulting complexes to the cell surface. The cysteine …

Mice deficient for the major lysosomal aspartic proteinase cathepsin D, generated by gene
targeting, develop normally during the first 2 weeks, stop thriving in the third week and die in …

Cathepsins have been implicated in the degradation of proteins destined for the MHC class
II processing pathway and in the proteolytic removal of invariant chain (Ii), a critical regulator …

Susceptibility to different diseases among related species, such as coho salmon
(Oncorhynchus kisutch), rainbow trout (Oncorhyncus mykiss) and Atlantic salmon (Salmo …

Intracellular degradation by autophagy plays a role in the maintenance of cellular
homeostasis under normal conditions and during periods of cellular stress. Autophagy has …

Background: The specific targeting of nanomedicines to mannose receptors, highly
expressed in cells of the immune system, performs a useful strategy for improving the …