[HTML][HTML] Cytoplasmic RNA decay pathways-Enzymes and mechanisms
A Łabno, R Tomecki, A Dziembowski - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work
conducted over the last decades has defined the major mRNA decay pathways, as well as …
conducted over the last decades has defined the major mRNA decay pathways, as well as …
Mechanisms of regulation of mature miRNAs
miRNAs are short RNA molecules of∼ 22-nt in length that play important roles in post-
transcriptional control of gene expression. miRNAs normally function as negative regulators …
transcriptional control of gene expression. miRNAs normally function as negative regulators …
Genetic changes associated with relapse in favorable histology Wilms tumor: A Children's Oncology Group AREN03B2 study
Over the last decade, sequencing of primary tumors has clarified the genetic underpinnings
of Wilms tumor but has not affected therapy, outcome, or toxicity. We now sharpen our focus …
of Wilms tumor but has not affected therapy, outcome, or toxicity. We now sharpen our focus …
SERRATE interacts with the nuclear exosome targeting (NEXT) complex to degrade primary miRNA precursors in Arabidopsis
M Bajczyk, H Lange, D Bielewicz, L Szewc… - Nucleic Acids …, 2020 - academic.oup.com
SERRATE/ARS2 is a conserved RNA effector protein involved in transcription, processing
and export of different types of RNAs. In Arabidopsis, the best-studied function of SERRATE …
and export of different types of RNAs. In Arabidopsis, the best-studied function of SERRATE …
[HTML][HTML] The 3'to 5'exoribonuclease DIS3: from structure and mechanisms to biological functions and role in human disease
DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein
complex involved in the 3'to 5'degradation and processing of both nuclear and cytoplasmic …
complex involved in the 3'to 5'degradation and processing of both nuclear and cytoplasmic …
The roles of the exoribonucleases DIS3L2 and XRN1 in human disease
RNA degradation is a vital post-transcriptional process which ensures that transcripts are
maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved …
maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved …
Rapid decay of engulfed extracellular miRNA by XRN1 exonuclease promotes transient epithelial-mesenchymal transition
J Zangari, M Ilie, F Rouaud, L Signetti… - Nucleic acids …, 2017 - academic.oup.com
Extracellular vesicles (EVs) have been shown to play an important role in intercellular
communication as carriers of DNA, RNA and proteins. While the intercellular transfer of …
communication as carriers of DNA, RNA and proteins. While the intercellular transfer of …
RNA-binding proteins and exoribonucleases modulating miRNA in cancer: the enemy within
Y Seo, J Rhim, JH Kim - Experimental & Molecular Medicine, 2024 - nature.com
Recent progress in the investigation of microRNA (miRNA) biogenesis and the miRNA
processing machinery has revealed previously unknown roles of posttranscriptional …
processing machinery has revealed previously unknown roles of posttranscriptional …
Comparative profiling of microRNAs in the winged and wingless English grain aphid, Sitobion avenae (F.) (Homoptera: Aphididae)
MicroRNAs (miRNAs) are short single-stranded non-coding RNAs that regulate gene
expression, particularly during development. In this study, 345 miRNAs were identified from …
expression, particularly during development. In this study, 345 miRNAs were identified from …
Collaborative control of cell cycle progression by the RNA exonuclease Dis3 and Ras is conserved across species
Dis3 encodes a conserved RNase that degrades or processes all RNA species via an N-
terminal PilT N terminus (PIN) domain and C-terminal RNB domain that harbor, respectively …
terminal PilT N terminus (PIN) domain and C-terminal RNB domain that harbor, respectively …