Any opinions, findings, and conclusions or recommendations expressed in this material are
those of the authors and do not necessarily reflect the views of the US Army Contracting …

The purpose of this work is to identify and synthesize research produced since the second
edition of these Guidelines was published and incorporate new results into revised evidence …

Pediatric acute liver failure (PALF) is a rare, rapidly progressive clinical syndrome with
significant morbidity and mortality. The phenotype of PALF manifests as abrupt onset liver …

Objectives: To produce a treatment algorithm for the ICU management of infants, children,
and adolescents with severe traumatic brain injury. Data Sources: Studies included in the …

Background: To compare the effects of 3% hypertonic saline solution and 20% mannitol
solution on intracranial hypertension. Methods: WAN-FANGDATA, CNKI, and CQVIP …

Acute liver failure (ALF) is a dynamic clinical condition manifested by an abrupt onset of a
liver-based coagulopathy and biochemical evidence of hepatocellular injury resulting from …

Despite decades of basic and clinical research, treatments to improve outcomes after
traumatic brain injury (TBI) are limited. However, based on the recent recognition of the …

Background: Mannitol and hypertonic saline are widely used to treat raised intracranial
pressure (ICP) after traumatic brain injury (TBI), but the clinical superiority of one over the …

Background: We performed a meta-analysis to evaluate the effect of hypertonic saline
compared to mannitol for the management of elevated intracranial pressure in traumatic …

Background Traumatic brain injury has a crippling impact on sufferers' quality of life, and
numerous therapy techniques are being researched to address this problem. In this study …