Mechanical properties of female reproductive organs and supporting connective tissues: a review of the current state of knowledge

A Baah-Dwomoh, J McGuire… - Applied …, 2016 - asmedigitalcollection.asme.org
Although there has been an upsurge of interest in research on women's sexual and
reproductive health, most of the research has remained confined to the obstetrics and …

Evidence for menopause as a sex-specific risk factor for glaucoma

A Douglass, M Dattilo, AJ Feola - Cellular and molecular neurobiology, 2023 - Springer
Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by
progressive loss of visual function and retinal ganglion cells (RGC). Current …

Changes in tissue composition of the vaginal wall of premenopausal women with prolapse

MH Kerkhof, AM Ruiz-Zapata, H Bril… - American journal of …, 2014 - Elsevier
Objective The objective of this study was to compare histological and biochemical features
of the (normal) precervical anterior vaginal wall and the prolapsed anterior vaginal wall of …

[HTML][HTML] Vaginal fibroblastic cells from women with pelvic organ prolapse produce matrices with increased stiffness and collagen content

AM Ruiz-Zapata, MH Kerkhof, S Ghazanfari… - Scientific reports, 2016 - nature.com
Pelvic organ prolapse (POP) is characterised by the weakening of the pelvic floor support
tissues, and often by subsequent prolapse of the bladder outside the body, ie cystocele. The …

Anisotropy of the passive and active rat vagina under biaxial loading

A Huntington, E Rizzuto, S Abramowitch… - Annals of Biomedical …, 2019 - Springer
Pelvic organ prolapse, the descent of the pelvic organs from their normal anatomical
position, is a common condition among women that is associated with mechanical …

Role of fibulin-5 insufficiency and prolapse progression on murine vaginal biomechanical function

GL Clark-Patterson, S Roy, L Desrosiers, LR Knoepp… - Scientific reports, 2021 - nature.com
The vagina plays a critical role in supporting the pelvic organs and loss of support leads to
pelvic organ prolapse. It is unknown what microstructural changes influence prolapse …

Biomechanical properties of the pelvic floor and its relation to pelvic floor disorders

AM Ruiz-Zapata, AJ Feola, J Heesakkers… - European Urology …, 2018 - Elsevier
Pelvic organ prolapse and stress urinary incontinence remain a clinical challenge as they
have unclear pathophysiology and suboptimal treatments. These common pelvic floor …

scRNA-seq reveals aging-related immune cell types and regulators in vaginal wall from elderly women with pelvic organ prolapse

Y Miao, J Wen, L Wang, Q Wen, J Cheng… - Frontiers in …, 2023 - frontiersin.org
Introduction In the pathology of pelvic organ prolapse (POP), little is known about the
contributing role of pelvic microenvironment. Also, the age-related differences in pelvic …

Age and menopause effects on ocular compliance and aqueous outflow

AJ Feola, JM Sherwood, MT Pardue… - … & visual science, 2020 - iovs.arvojournals.org
Purpose: Glaucoma is the second leading cause of blindness worldwide. Recent work
suggests that estrogen and the timing of menopause play a role in modulating the risk of …

Development and preclinical investigation of physically cross-linked and ph-sensitive polymeric gels as potential vaginal contraceptives

A Rochani, V Agrahari, N Chandra, ON Singh… - Polymers, 2022 - mdpi.com
This study explored the development of cross-linked gels to potentially provide a physical
barrier to vaginal sperm transport for contraception. Two types of gels were formulated, a …