Long-term primary culture of mammalian cells has been always difficult due to unavoidable
senescence. Conventional methods for generating immortalized cell lines usually require …

Telomere and telomerase play important roles in abnormal cell proliferation, metastasis,
stem cell maintenance, and immortalization in various cancers. Therefore, designing of …

Chromosomal rearrangements have been shown to alter genome organization,
consequently having an impact on gene expression. Studies on certain types of leukemia …

Melanocytes (MCs) are specialized cells that synthesize melanin within the melanosome.
Cultured MCs are useful in order to study their role in relation to pigmentation. However, MC …

The of cellular composition pr proteins protein can be cumulati ocesses vely inv r ol ef v is ed
vital in the for maint the maint enance enance of cellular of cell aggr of pr eg ot at eostasis …

Telomerase can overcome replicative senescence by elongation of telomeres but is also a
specific element in most cancer cells. It is expressed more vastly than any other tumor …

Recent demographic studies predict there will be a considerable increase in the number of
elderly people within the next few decades. Aging has been recognized as one of the main …

As the economic burden associated with vision loss and ocular damage continues to rise,
there is a need to explore novel treatment strategies. Extracellular vesicles (EVs) are …

Nearly 460 million individuals are affected by sensorineural hearing loss (SNHL), one of the
most common human sensory disorders. In mammals, hearing loss is permanent due to the …

Functional human brown and white adipose tissue (BAT and WAT) are vital for
thermoregulation and nutritional homeostasis, while obesity and other stressors lead …