Background: High monocyte to lymphocyte ratio (MLR) values may be associated with the
risk of active tuberculosis (TB) infection in adults, infants, and postpartum women with HIV …

Tuberculosis (TB) remains a global health problem despite almost universal efforts to
provide patients with highly effective chemotherapy, in part, because many infected …

Mycobacterium tuberculosis (Mtb) is responsible for approximately 1.5 million deaths each
year. Though 10% of patients develop tuberculosis (TB) after infection, 90% of these …

Summary The 2013 Ebola epidemic in Central and West Africa heralded the emergence of
wide-spread, highly pathogenic viruses. The successful recombinant vector vaccine against …

Monocytes were critical cells in the innate immune system. Monocyte recruitment to the
lungs is a crucial process of pathophysiology in chronic obstructive pulmonary disease …

Objectives To identify new potential host biomarkers in blood to discriminate between active
TB patients, uninfected (NoTBI) and latently infected contacts (LTBI). Methods A blood cell …

Non-human primate models of Tuberculosis (TB) are one of the most commonly used within
the experimental TB field because they closely mimic the whole spectrum of disease …

Non-human primates (NHPs) are used extensively in the development of vaccines and
therapeutics for human disease. High standards in the design, conduct, and reporting of …

There is a sex bias in tuberculosis's severity, prevalence, and pathogenesis, and the rates
are higher in men. Immunological and physiological factors are fundamental contributors to …

Rhesus (Macaca mulatta) and cynomolgus (Macaca fasicularis) macaques of distinct
genetic origin are understood to vary in susceptibility to Mycobacterium tuberculosis, and …