Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …

Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …

Covering: 2009 to 2013 To date approximately 100 000 fungal species are known although
far more than one million are expected. The variety of species and the diversity of their …

The enzymes acyl-coenzyme A (CoA): cholesterol acyltransferases (ACATs) are membrane-
bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form …

Mammalian cells acquire cholesterol from low-density lipoprotein (LDL) and from
endogenous biosynthesis. The roles of the Niemann-Pick type C1 protein in mediating the …

Over one hundred different phospholipid molecular species are known to be present in
mammalian cells and tissues. Fatty acid remodeling systems for phospholipids including …

Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein
capable of transferring neutral lipids between membrane vesicles. Its role as an essential …

Nuclear factor erythroid-2 related factor 2 (Nrf2) plays a pivotal role in cytoprotection against
both endogenous and exogenous stresses. Here, we establish a novel molecular link …

Context and Objective: In most populations a greater proportion of men have hepatic
steatosis than women. Sex-specific differences in hepatic dietary fatty acid (FA) metabolism …