Modern medicine has been waging a war on cancer for nearly a century with no tangible
end in sight. Cancer treatments have significantly progressed, but the need to increase …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …

One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …

Significant progress has been made in the understanding of lung cancer biology, due in
large part to advancement in the understanding of tumor biology and pathogenesis …

Cancer cells reprogram their metabolism, altering both uptake and utilization of extracellular
nutrients. We individually depleted amino acid nutrients from isogenic cells expressing …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about
half of these tumors express the EGFRvIII variant. The prognostic role of EGFRvIII in EGFR …

The cancer stem cell (CSC) hypothesis has gained significant recognition as a descriptor of
tumorigenesis. Additionally, tumor-associated macrophages (TAMs) are known to promote …

Constitutive activation of the EGFR is common in cancer due to EGFR wild-type (EGFRwt)
overexpression or the presence of mutant EGFR. Signaling by constitutively active NSCLC …

Inappropriate activation of the receptor tyrosine kinase EGFR contributes to a variety of
human malignancies. Here we show a mechanism to induce vulnerability to an existing first …