Cytokine-mediated communication: a quantitative appraisal of immune complexity

G Altan-Bonnet, R Mukherjee - Nature Reviews Immunology, 2019 - nature.com
Intercellular communication mediated by cytokines is the main mechanism by which cells of
the immune system talk to each other. Many aspects of cytokine signalling in the immune …

Combination therapy of killing diseases by injectable hydrogels: from concept to medical applications

F Poustchi, H Amani, Z Ahmadian… - Advanced …, 2021 - Wiley Online Library
The complexity of hard‐to‐treat diseases strongly undermines the therapeutic potential of
available treatment options. Therefore, a paradigm shift from monotherapy toward …

Inferring microenvironmental regulation of gene expression from single-cell RNA sequencing data using scMLnet with an application to COVID-19

J Cheng, J Zhang, Z Wu, X Sun - Briefings in bioinformatics, 2021 - academic.oup.com
Inferring how gene expression in a cell is influenced by cellular microenvironment is of great
importance yet challenging. In this study, we present a single-cell RNA-sequencing data …

Extracellular vesicles: evolving factors in stem cell biology

M Nawaz, F Fatima, KC Vallabhaneni… - Stem cells …, 2016 - Wiley Online Library
Stem cells are proposed to continuously secrete trophic factors that potentially serve as
mediators of autocrine and paracrine activities, associated with reprogramming of the tumor …

[HTML][HTML] Mathematical modeling of therapy-induced cancer drug resistance: connecting cancer mechanisms to population survival rates

X Sun, J Bao, Y Shao - Scientific reports, 2016 - nature.com
Drug resistance significantly limits the long-term effectiveness of targeted therapeutics for
cancer patients. Recent experimental studies have demonstrated that cancer cell …

Wnt signaling in liver fibrosis: progress, challenges and potential directions

C Miao, Y Yang, X He, C Huang, Y Huang, L Zhang… - Biochimie, 2013 - Elsevier
Liver fibrosis is a common wound-healing response to chronic liver injuries, including
alcoholic or drug toxicity, persistent viral infection, and genetic factors. Myofibroblastic …

[HTML][HTML] Extracellular vesicles, tunneling nanotubes, and cellular interplay: synergies and missing links

M Nawaz, F Fatima - Frontiers in molecular biosciences, 2017 - frontiersin.org
The process of intercellular communication seems to have been a highly conserved
evolutionary process. Higher eukaryotes use several means of intercellular communication …

Single-cell transcriptome-based multilayer network biomarker for predicting prognosis and therapeutic response of gliomas

J Zhang, M Guan, Q Wang, J Zhang… - Briefings in …, 2020 - academic.oup.com
Occurrence and development of cancers are governed by complex networks of interacting
intercellular and intracellular signals. The technology of single-cell RNA sequencing (scRNA …

Skeletal myogenic differentiation of urine-derived stem cells and angiogenesis using microbeads loaded with growth factors

G Liu, RA Pareta, R Wu, Y Shi, X Zhou, H Liu, C Deng… - Biomaterials, 2013 - Elsevier
To provide site-specific delivery and targeted release of growth factors to implanted urine-
derived stem cells (USCs), we prepared microbeads of alginate containing growth factors …

Carrier-free functionalized multidrug nanorods for synergistic cancer therapy

M Zhou, X Zhang, Y Yang, Z Liu, B Tian, J Jie, X Zhang - Biomaterials, 2013 - Elsevier
We developed carrier-free multidrug nanocrystals (MDNCs) for the combination
chemotherapy with synergistic effect, improved tolerance and imaging capability for cancer …