Pathogen at the gates: human cytomegalovirus entry and cell tropism
The past few years have brought substantial progress toward understanding how human
cytomegalovirus (HCMV) enters the remarkably wide spectrum of cell types and tissues that …
cytomegalovirus (HCMV) enters the remarkably wide spectrum of cell types and tissues that …
Programming cytomegalovirus as an HIV vaccine
The initial development of cytomegalovirus (CMV) as a vaccine vector for HIV/simian
immunodeficiency virus (SIV) was predicated on its potential to pre-position high-frequency …
immunodeficiency virus (SIV) was predicated on its potential to pre-position high-frequency …
New therapies for human cytomegalovirus infections
WJ Britt, MN Prichard - Antiviral research, 2018 - Elsevier
The recent approval of letermovir marks a new era of therapy for human cytomegalovirus
(HCMV) infections, particularly for the prevention of HCMV disease in hematopoietic stem …
(HCMV) infections, particularly for the prevention of HCMV disease in hematopoietic stem …
CMV immune evasion and manipulation of the immune system with aging
Human cytomegalovirus (HCMV) encodes numerous proteins and microRNAs that function
to evade the immune response and allow the virus to replicate and disseminate in the face …
to evade the immune response and allow the virus to replicate and disseminate in the face …
[HTML][HTML] Cytomegalovirus-vaccine-induced unconventional T cell priming and control of SIV replication is conserved between primate species
D Malouli, RM Gilbride, HL Wu, JM Hwang, N Maier… - Cell host & …, 2022 - cell.com
Strain 68-1 rhesus cytomegalovirus expressing simian immunodeficiency virus (SIV)
antigens (RhCMV/SIV) primes MHC-E-restricted CD8+ T cells that control SIV replication in …
antigens (RhCMV/SIV) primes MHC-E-restricted CD8+ T cells that control SIV replication in …
Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy
MC Verweij, SG Hansen, R Iyer, N John, D Malouli… - Science, 2021 - science.org
INTRODUCTION Strain 68-1 rhesus cytomegalovirus (RhCMV) vaccine vectors expressing
simian immunodeficiency virus (SIV) antigens elicit immune responses that stringently …
simian immunodeficiency virus (SIV) antigens elicit immune responses that stringently …
Herpesvirus evasion of natural killer cells
Natural killer (NK) cells play an important role in the host response against viral infections
and cancer development. They are able to kill virus-infected and tumor cells, and they …
and cancer development. They are able to kill virus-infected and tumor cells, and they …
Subversion of immune response by human cytomegalovirus
ARK Patro - Frontiers in Immunology, 2019 - frontiersin.org
Human cytomegalovirus (HCMV) is the most common cause of congenital infections and is
an important pathogen in immunocompromised individuals. Despite a robust host immune …
an important pathogen in immunocompromised individuals. Despite a robust host immune …
Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses
ECY Wang, M Pjechova… - Proceedings of the …, 2018 - National Acad Sciences
CD58 is an adhesion molecule that is known to play a critical role in costimulation of effector
cells and is intrinsic to immune synapse structure. Herein, we describe a virally encoded …
cells and is intrinsic to immune synapse structure. Herein, we describe a virally encoded …
Rhesus monkeys for a nonhuman primate model of cytomegalovirus infections
HL Itell, A Kaur, JD Deere, PA Barry… - Current opinion in virology, 2017 - Elsevier
Highlights•Nonhuman primate (NHP) CMVs are most closely related to human CMV
(HCMV).•Rhesus CMV (RhCMV) bears numerous genomic and functional similarities to …
(HCMV).•Rhesus CMV (RhCMV) bears numerous genomic and functional similarities to …