Chromatin remodellers as therapeutic targets
HA Malone, CWM Roberts - Nature Reviews Drug Discovery, 2024 - nature.com
Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …
Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
L Duplaquet, K So, AW Ying, SP Choudhuri, X Li… - Cancer Cell, 2024 - cell.com
Small cell lung cancers (SCLCs) are composed of heterogeneous subtypes marked by
lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3 …
lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3 …
Transcription factor dependencies identify BAF-dependent cancers
HM McRae, DC Hargreaves - Cancer Cell, 2024 - cell.com
In Cancer Cell, Bolomsky et al., Duplaquet et al., and He et al. identify cancers that are
dependent on the BAF chromatin remodeling complex, specifically IRF4-driven multiple …
dependent on the BAF chromatin remodeling complex, specifically IRF4-driven multiple …
Androgen receptor-negative prostate cancer is vulnerable to SWI/SNF-targeting degrader molecules
The switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complex is frequently
deregulated during progression to castration-resistant prostate cancer (CRPC). Proteolysis …
deregulated during progression to castration-resistant prostate cancer (CRPC). Proteolysis …