Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …

Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be
observed both at the cartilage surface and in its deeper layers. The formation of calcium …

Osteoarthritis (OA) is a chronic, progressive degenerative whole joint disease that affects the
articular cartilage, subchondral bone, ligaments, capsule, and synovium. While it is still …

Osteoarthritis (OA) is the most common degenerative joint disease and no disease-
modifying therapy for OA is currently available. Targeting articular cartilage alone may not …

Bisphosphonates have been proposed as possible disease-modifying drugs in
osteoarthritis. However, the evidence of their efficacy is poor and their outcomes presented a …

Extracellular vesicles have gained wide momentum as potential therapeutics for
osteoarthritis, a highly prevalent chronic disease that still lacks an approved treatment. The …

Bisphosphonates (BP) are considered a treatment option for osteoarthritis (OA) due to
reduction of OA-induced microtrauma in the bone marrow, stabilization of subchondral bone …

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by pain and
cartilage damage. Intra-articular (ia) viscosupplementation with hyaluronic acid (HA) is …

Introduction Previous studies in animal models of osteoarthritis suggest that alendronate
(ALN) has antiresorptive and chondroprotective effects, and can reduce osteophyte …

Posttraumatic osteoarthritis (PTOA) is associated with abnormal and increased subchondral
bone remodeling. Inhibiting altered remodeling immediately following joint damage can …