Pancreatic cancer (PC) remains a leading cause of mortality worldwide due to the absence
of early detection methods and the low success rates of traditional therapeutic strategies …

Pancreatic Ductal Adenocarcinoma (PDAC) is projected to become the 2nd leading cause of
cancer-related deaths in the United States. Limitations in early detection and treatment …

Periostin (POSTN), a matricellular protein predominantly secreted by cancer-associated
fibroblasts (CAFs), has emerged as a key regulator of cancer progression and therapy …

The chemoresistance of pancreatic cancer tumors urgently needs to be addressed.
Pancreatic cancer is characterized by an abundant stroma, with significant fibrous …

Collagen contributes to extracellular matrix formation and stiffness, providing a three-
dimensional framework that supports the development and growth of solid tumors. By …

Pancreatic cancer is a particularly aggressive tumor, distinguished by the presence of a
prominent collagenous stroma and desmoplasia that envelops the tumor cells. Pancreatic …

Les chimiothérapies atteignent la tumeur par le système vasculaire, faisant de la quantité et
la qualité des vaisseaux sanguins un régulateur clé de l'efficacité des drogues. Or, dans …

Pancreatic ductal adenocarcinoma (PDAC) is a disease with dismal prognosis. With five-
year survival rates of less than 11%, PDAC is set to become the second leading cause of …